Ligand Promoted meta-C-H Chlorination of Anilines and Phenols

被引：104

作者：

Shi, Hang ^{[1
]}

Wang, Peng ^{[1
]}

Suzuki, Shin ^{[1
]}

Farmer, Marcus E. ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 45期

关键词：

PALLADIUM-CATALYZED SYNTHESIS; CROSS-COUPLING REACTIONS; AMINO-ACID LIGANDS; BOND ACTIVATION; ARYL CHLORIDES; AROMATIC FUNCTIONALIZATION; ARYLATION; TEMPLATE; ALKYLATION; NORBORNENE;

D O I：

10.1021/jacs.6b11055

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pd-catalyzed meta-C-H chlorination of anilines and phenols is developed using norbornene as the mediator. Heterocycles, including indole, thiophene, and indazole, are tolerated. The identification of a new pyridone-based ligand is crucial for the success of this meta-C-H chlorination reaction. Subsequent diverse transformations of the chlorinated products demonstrate the versatility of meta-C-H chlorination.

引用

页码：14876 / 14879

页数：4

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