Data on Wistar Hannover Rats from a General Toxicity Study

被引：4

作者：

Yamatoya, Hideyuki ^{[1
,2
,4
]}

Kawaguchi, Hiroaki ^{[1
,2
]}

Yajima, Kanako ^{[5
]}

Kadokura, Hidetomi ^{[4
]}

Yoshikawa, Tsuyoshi ^{[4
]}

Yamashita, Rie ^{[4
]}

Shiraishi, Mitsuya ^{[2
,3
]}

Miyamoto, Atsushi ^{[2
,3
]}

Miyoshi, Noriaki ^{[1
,2
]}

机构：

[1] Kagoshima Univ, Dept Vet Histopathol, Joint Fac Vet Med, Kagoshima 8900065, Japan

[2] Yamaguchi Univ, United Grad Sch Vet Sci, Yamaguchi 7538515, Japan

[3] Kagoshima Univ, Dept Vet Pharmacol, Joint Fac Vet Med, Kagoshima 8900065, Japan

[4] Shin Nippon Biomed Labs Ltd SNBL DSR, Drug Safety Res Labs, Kagoshima 8911394, Japan

[5] Shin Nippon Biomed Labs Ltd SNBL PBC, Pharmacokinet & Bioanal Ctr, Wakayama 6420017, Japan

来源：

EXPERIMENTAL ANIMALS | 2012年 / 61卷 / 04期

关键词：

clinical laboratory test; hepatic drug-metabolizing enzyme; pathological examination; SPRAGUE-DAWLEY RATS; LIVER MICROSOMES; SEX; BINDING; MICE;

D O I：

10.1538/expanim.61.467

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The aim of this study was to collect data on chronological changes in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes from Wistar Hannover rats at 8, 10, 19, and 32 weeks of age. The serum triglyceride concentration and the serum LDL cholesterol level were higher in males than in females at all ages. In contrast, serum total protein and creatinine concentrations and cholinesterase activity were lower in males than in females. In addition, sex differences were confirmed in pituitary weight and hepatic CYP3A2 and CYP2C11 activities. In conclusion, the general toxicological data noted in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes relating to chronological changes and sex differences may be useful in assessing drug-related toxicity in this strain.

引用

页码：467 / 476

页数：10

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