Carcinoma-associated fibroblasts in cancer: the great escape

被引：18

作者：

Albrengues, Jean ^{[1
]}

Meneguzzi, Guerrino ^{[1
]}

Gaggioli, Cedric ^{[1
]}

机构：

[1] Univ Nice Sophia Antipolis, Inst Rech Canc & Vieillissement, Fac Med, Inserm U1081,CNRS UMR7284,IRCAN, F-06107 Nice, France

来源：

M S-MEDECINE SCIENCES | 2014年 / 30卷 / 04期

关键词：

GROWTH-FACTOR-BETA; CELL INVASION; ACTIVATION; TRANSITION; SECRETION; TRIGGERS; MATRICES;

D O I：

10.1051/medsci/20143004012

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cellular and molecular crosstalks between cancer and non-cancer tumor-associated cells result in tumor growth and metastatic spreading. During carcinoma development, tumor cells secrete signaling molecules that influence the surrounding non-cancer cells, which, in return, favor tumor cell growth, survival, migration and metastasis. Carcinoma-associated fibroblasts (CAF) are the most abundant population of non-cancer cells found in tumors, and their presence is often associated with poor clinical prognosis. Here, we summarize the pro-carcinogenic roles of CAF cells during carcinogenesis, with a specific focus on their abilities to drive cancer cell-dependent pro-invasive extracellular matrix remodeling.

引用

页码：391 / 397

页数：7

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