Determination of 20(S)-protopanaxadiol in rat plasma by LC-MS/MS and its application to the pharmacokinetic study: A comparative study of its solution and two oral formulations

被引：7
作者：
Han, Meihua [1 ,2 ]
Chen, Jing [3 ]
Wang, Yuqin [4 ]
Chen, Shilin [1 ,2 ]
Wang, Xiangtao [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Beijing 100193, Peoples R China
[2] Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China
[3] Harbin Univ Commerce, Life Sci & Environm Sci Res Ctr, Engn Res Ctr Nat Anticanc Drugs, Minist Educ, Harbin 150076, Peoples R China
[4] SIRC TCM, Shanghai 201203, Peoples R China
来源：
JOURNAL OF ANALYTICAL CHEMISTRY | 2013年 / 68卷 / 08期
关键词：
20(S)-protopanaxadiol; high-performance liquid chromatography. tandem mass spectrometry method; MASS-SPECTROMETRY; GINSENOSIDE RG3; CELLS; PROLIFERATION; METABOLITES; RH2;
D O I：
10.1134/S106193481308008X
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A high-performance liquid chromatography - tandem mass spectrometry method was used in a comparative pharmacokinetic study on 20(S)-protopanaxadiol in its solution, pharmacosomes and hydroxy-propyl-beta-cyclodextrin inclusion compound. The calibration linearity range was 2.5-5000 ng/mL and the limit of quantification was 2.5 ng/mL. The intra- and inter-assay coefficients of variation were less than 7% and the recoveries were 67.4, 63.3 and 69.6% at 5, 250 and 4500 ng/mL. In contrast to 20(S)-protopanaxadiol solution, its pharmacosomes and hydroxypropyl-beta-cyclodextrin inclusion compound improved the oral bioavailability to different extent and meanwhile were much safer in clinical use.
引用
收藏
页码：730 / 735
页数：6
相关论文
共 50 条
[41]   Quantitative analysis of atractylenolide I in rat plasma by LC-MS/MS method and its application to pharmacokinetic study [J].
Li, Yujuan ;
Zhang, Yushi ;
Wang, Zhimin ;
Zhu, Jingjing ;
Tian, Yuan ;
Chen, Bo .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2012, 58 :172-176
[42]   Determination of amoxicillin in human plasma by LC-MS/MS and its application to a bioequivalence study [J].
Pingale, Satish G. ;
Badgujar, Madhukara ;
Mangaonkar, Kiran V. ;
Mastorakis, Nikos E. .
PROCEEDINGS OF THE WORLD MEDICAL CONFERENCE, 2010, :86-+
[43]   A validated LC-MS/MS method for the simultaneous determination of 20-(S)-protopanaxatriol and its two active metabolites in rat plasma: Application to a pharmacokinetics study [J].
Qiu, Xin ;
Yang, Jiali ;
Wang, Wei ;
Wu, Qiuhong ;
Shao, Hong .
JOURNAL OF SEPARATION SCIENCE, 2017, 40 (23) :4503-4510
[44]   LC-MS/MS determination of deoxyelephantopin, a novel anti-tumor candidate in rat plasma and its application to a pharmacokinetic study in rats [J].
Niu, Kai ;
Guo, Chunjie ;
Yan, Huiyu ;
Teng, Shiyong .
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2018, 28 (05) :582-588
[45]   An LC-MS/MS method for simultaneous determination of four flavonoids from Semen Oroxyli in rat plasma and its application to a pharmacokinetic study [J].
Zhang, Jing ;
Zhang, Sixi ;
Teng, Shiyong ;
Zhai, Lijie .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 1020 :96-102
[46]   Determination of L-(+)-bornesitol, the hypotensive constituent of Hancornia speciosa , in rat plasma by LC-MS/MS and its application on a pharmacokinetic study [J].
Moreira, Luciana N. ;
Feltrin, Clarissa ;
Goncalves, Jose E. ;
de Castro, Whocely, V ;
Simoes, Claudia M. O. ;
de Padua, Rodrigo M. ;
Cortes, Steyner F. ;
Braga, Fernao C. .
BIOMEDICINE & PHARMACOTHERAPY, 2020, 132
[47]   Determination of Poricoic Acid A in Rat Plasma after Oral and Intravenous Administration by LC-MS-MS and Its Application to a Pharmacokinetic Study [J].
Yin, Lian-Hong ;
Xu, Li-Na ;
Han, Xu ;
Xu, You-Wei ;
Qi, Yan ;
Peng, Jin-Yong .
CHROMATOGRAPHIA, 2010, 72 (5-6) :465-472
[48]   Simultaneous determination of three major lignans in rat plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Diphylleia sinensis extract [J].
Zhao, Chengliang ;
Zhang, Nan ;
He, Weiyan ;
Li, Rui ;
Shi, Dan ;
Pang, Li ;
Dong, Ning ;
Xu, Hong ;
Ji, Honglei .
BIOMEDICAL CHROMATOGRAPHY, 2014, 28 (04) :463-467
[49]   Determination of Sodium Tanshinone IIA Sulfonate in human plasma by LC-MS/MS and its application to a clinical pharmacokinetic study [J].
Qin, WeiWei ;
Wang, Bin ;
Lu, XiaoPei ;
Liu, HaiMing ;
Wang, Li ;
Qi, WeiLin .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 121 :204-208
[50]   LC-MS/MS Method Development and Validation of Lenvatinib and its Related Impurities in Rat Plasma: Application to a Pharmacokinetic Study [J].
Talari, Subrahmanyam ;
Vejendla, Anuradha ;
Boddapati, S. N. Murthy ;
Kalidindi, Johar .
CURRENT PHARMACEUTICAL ANALYSIS, 2022, 18 (06) :614-628
12345