Sickle Cell Trait from a Metabolic, Renal, and Vascular Perspective: Linking History, Knowledge, and Health

被引:9
作者
Thoreson, Caroline K. [1 ]
O'Connor, Michelle Y. [1 ]
Ricks, Madia [1 ]
Chung, Stephanie T. [1 ]
Sumner, Anne E. [1 ]
机构
[1] NIDDK, Diabet Endocrinol & Obes Branch, NIH, Bld 10 CRC,Rm 6-5940,MSC 1612 9000 Rockville Pike, Bethesda, MD 20892 USA
关键词
Sickle cell trait; Newborn screening; Exercise-related sudden death; Exertional sickling; Hematuria; Stroke; SUDDEN-DEATH; RISK-FACTOR; PAPILLARY NECROSIS; DIABETES-MELLITUS; GROSS HEMATURIA; BLOOD RHEOLOGY; DISEASE; RHABDOMYOLYSIS; ABNORMALITIES; COMPLICATIONS;
D O I
10.1007/s40615-014-0077-4
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Sickle cell trait (SCT) is at the intersection of genetics, social policy, and medicine. SCT occurs in three-hundred million people worldwide and in approximately 8 % of African-Americans. There has been great debate about the influence of SCT on health. Yet data exist, albeit controversial, which suggest that SCT is associated with metabolic derangements that can lead to sudden death after vigorous physical activity, renal dysfunction, thromboembolic events, and stroke. In addition, it has even been postulated that SCT might enhance the vascular complications of diabetes. This review focuses on (a) the scientific breakthroughs that led to the discovery of hemoglobin S, sickle cell disease, and SCT, (b) the history of screening programs in the United States, (c) the incidence and etiology of exercise-related sudden death in military personnel and athletes with SCT, and (d) the data examining the potential chronic disease consequences of SCT from a metabolic, renal, and vascular perspective.
引用
收藏
页码:330 / 335
页数:6
相关论文
共 66 条
  • [11] BRISTOW LR, 1974, WESTERN J MED, V121, P77
  • [12] Sickle Cell Trait and Incident Ischemic Stroke in the Atherosclerosis Risk in Communities Study
    Caughey, Melissa C.
    Loehr, Laura R.
    Key, Nigel S.
    Derebail, Vimal K.
    Gottesman, Rebecca F.
    Kshirsagar, Abhijit V.
    Grove, Megan L.
    Heiss, Gerardo
    [J]. STROKE, 2014, 45 (10) : 2863 - 2867
  • [13] CHIU D, 1981, BLOOD, V58, P398
  • [14] Blood rheology abnormalities and vascular cell adhesion mechanisms in sickle cell trait carriers during exercise
    Connes, Philippe
    Hue, Olivier
    Tripette, Julien
    Hardy-Dessources, Marie-Dominique
    [J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 2008, 39 (1-4) : 179 - 184
  • [15] Cook JE, 1915, ARCH INTERN MED, V16, P644
  • [16] Cooley TB, 1926, AM J DIS CHILD, V32, P334
  • [17] Full Accounting of Diabetes and Pre-Diabetes in the US Population in 1988-1994 and 2005-2006
    Cowie, Catherine C.
    Rust, Keith F.
    Ford, Earl. S.
    Eberhardt, Mark S.
    Byrd-Holt, Danita D.
    Li, Chaoyang
    Williams, Desmond E.
    Gregg, Edward W.
    Bainbridge, Kathleen E.
    Saydah, Sharon H.
    Geiss, Linda S.
    [J]. DIABETES CARE, 2009, 32 (02) : 287 - 294
  • [18] GROSS HEMATURIA IN SICKLE-CELL TRAIT - A REPORT OF 8 CASES
    CRONE, RI
    JEFFERSON, SC
    PILEGGI, VJ
    LOWRY, EC
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1957, 100 (04) : 597 - 603
  • [19] High Prevalence of Sickle Cell Trait in African Americans with ESRD
    Derebail, Vimal K.
    Nachman, Patrick H.
    Key, Nigel S.
    Ansede, Heather
    Falk, Ronald J.
    Kshirsagar, Abhijit V.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 21 (03): : 413 - 417
  • [20] Sickle cell trait is not a risk factor for stroke
    Dowling, MM
    [J]. ARCHIVES OF NEUROLOGY, 2005, 62 (11) : 1780 - 1781