Long Interspersed Element-1 Methylation Level as a Prognostic Biomarker in Gastrointestinal Cancers

被引：46
作者：
Baba, Yoshifumi [1 ]
Yagi, Taisuke [1 ]
Sawayama, Hiroshi [1 ]
Hiyoshi, Yukiharu [1 ]
Ishimoto, Takatsugu [1 ]
Iwatsuki, Masaaki [1 ]
Miyamoto, Yuji [1 ]
Yoshida, Naoya [1 ]
Baba, Hideo [1 ]
机构：
[1] Kumamoto Univ, Grad Sch Med Sci, Dept Gastroenterol Surg, 1-1-1 Honjo, Kumamoto 8608556, Japan
来源：
DIGESTION | 2018年 / 97卷 / 01期
基金：
日本学术振兴会;
关键词：
Epigenetics; Methylation; Long interspersed element-1; Gastrointestinal cancer; Prognosis; LINE-1; HYPOMETHYLATION; RETROTRANSPOSONS; SEQUENCES; INDUCTION;
D O I：
10.1159/000484104
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Epigenetic changes play a crucial role in human cancer development. DNA methylation is a central epigenetic process that regulates levels of gene expression. Changes in DNA methylation that occur in human tumors include global DNA hypomethylation and site-specific CpG island promoter hypermethylation. Long interspersed element-1 (LINE-1) is a repetitive DNA retrotransposon that duplicates via a copy-and-paste genetic mechanism. As LINE-1 constitutes approximately 17% of the human genome, the extent of LINE-1 methylation is regarded as a surrogate marker of global DNA methylation. In a variety of gastrointestinal (GI) cancers, LINE-1 hypomethylation is strongly associated with a poor prognosis, supporting its potential role as a prognostic biomarker. In this article, we summarize current knowledge regarding LINE-1 methylation and its prognostic impact in GI cancers. (c) 2018 S. Karger AG, Basel
引用
收藏
页码：26 / 30
页数：5
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