Morphogen gradients - New insights from DPP

被引：99

作者：

Podos, SD ^{[1
]}

Ferguson, EL ^{[1
]}

机构：

[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

来源：

TRENDS IN GENETICS | 1999年 / 15卷 / 10期

关键词：

D O I：

10.1016/S0168-9525(99)01854-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Drosophila TGF beta family member Decapentaplegic (DPP) has been proposed to function as a morphogen to pattern cell fields in a number of developmental contexts. A series of recent: reports add significantly to our knowledge of the mechanisms of DPP-gradient formation and interpretation. These reports identify additional genes and genetic circuitry necessary for this patterning system, and they highlight variations that might reflect developmental constraints within individual target cell fields.

引用

页码：396 / 402

页数：7

共 46 条

[1] THE SCREW GENE ENCODES A UBIQUITOUSLY EXPRESSED MEMBER OF THE TGF-BETA FAMILY REQUIRED FOR SPECIFICATION OF DORSAL CELL FATES IN THE DROSOPHILA EMBRYO [J].

ARORA, K ;

LEVINE, MS ;

OCONNOR, MB .

GENES & DEVELOPMENT, 1994, 8 (21) :2588-2601

[2] Local inhibition and long-range enhancement of Dpp signal transduction by Sog [J].

Ashe, HL ;

Levine, M .

NATURE, 1999, 398 (6726) :427-431

[3] CHARACTERIZATION AND RELATIONSHIP OF DPP RECEPTORS ENCODED BY THE SAXOPHONE AND THICK VEINS GENES IN DROSOPHILA [J].

BRUMMEL, TJ ;

TWOMBLY, V ;

MARQUES, G ;

WRANA, JL ;

NEWFELD, SJ ;

ATTISANO, L ;

MASSAGUE, J ;

OCONNOR, MB ;

GELBART, WM .

CELL, 1994, 78 (02) :251-261

[4] Transducing the Dpp morphogen gradient in the wing of Drosophila:: Regulation of Dpp targets by brinker [J].

Campbell, G ;

Tomlinson, A .

CELL, 1999, 96 (04) :553-562

[5] Smad8 mediates the signaling of the receptor serine kinase [J].

Chen, Y ;

Bhushan, A ;

Vale, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (24) :12938-12943

[6] Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors [J].

Chen, YG ;

Massagué, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (06) :3672-3677

[7] The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors [J].

Dyson, S ;

Gurdon, JB .

CELL, 1998, 93 (04) :557-568

[8]

FERGUSON EL, 1992, DEVELOPMENT, V114, P583

[9] DECAPENTAPLEGIC ACTS AS A MORPHOGEN TO ORGANIZE DORSAL-VENTRAL PATTERN IN THE DROSOPHILA EMBRYO [J].

FERGUSON, EL ;

ANDERSON, KV .

CELL, 1992, 71 (03) :451-461

[10] XENOPUS CHORDIN AND DROSOPHILA SHORT GASTRULATION GENES ENCODE HOMOLOGOUS PROTEINS FUNCTIONING IN DORSAL-VENTRAL AXIS FORMATION [J].

FRANCOIS, V ;

BIER, E .

CELL, 1995, 80 (01) :19-20

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