Early versus delayed umbilical cord clamping in infants with congenital heart disease: a pilot, randomized, controlled trial

被引:27
作者
Backes, C. H. [1 ,2 ,3 ,4 ]
Huang, H. [1 ,3 ]
Cua, C. L. [2 ,3 ]
Garg, V. [2 ,3 ,5 ]
Smith, C. V. [6 ]
Yin, H. [7 ]
Galantowicz, M. [2 ,3 ,8 ]
Bauer, J. A. [1 ,3 ]
Hoffman, T. M. [2 ,3 ]
机构
[1] Nationwide Childrens Hosp, Ctr Perinatal Res, Columbus, OH 43205 USA
[2] Nationwide Childrens Hosp, Ctr Heart, Columbus, OH 43205 USA
[3] Nationwide Childrens Hosp, Dept Pediat, Columbus, OH 43205 USA
[4] Ohio State Univ, Wexner Med Ctr, Dept Obstet Gynecol, Columbus, OH 43210 USA
[5] Nationwide Childrens Hosp, Ctr Cardiovasc & Pulm Res, Columbus, OH 43205 USA
[6] Univ Washington, Sch Med, Seattle Childrens Res Inst, Ctr Dev Therapeut, Seattle, WA USA
[7] Nationwide Childrens Hosp, Biostat Core, Columbus, OH 43205 USA
[8] Ohio State Univ, Wexner Med Ctr, Nationwide Childrens Hosp, Dept Cardiothorac Surg, Columbus, OH 43210 USA
关键词
CARDIOPULMONARY BYPASS; BLOOD-TRANSFUSION; POSTOPERATIVE MORBIDITY; PLACENTAL TRANSFUSION; TERM; PRETERM; HEMATOCRIT; MORTALITY; OPERATION; VISCOSITY;
D O I
10.1038/jp.2015.89
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Delayed umbilical cord clamping (DCC) at birth may provide a better neonatal health status than early umbilical cord clamping (ECC). However, the safety and feasibility of DCC in infants with congenital heart disease (CHD) have not been tested. This was a pilot, randomized, controlled trial to establish the safety and feasibility of DCC in neonates with CHD. STUDY DESIGN: Pregnant women admitted 437 weeks gestational age with prenatal diagnosis of critical CHD were enrolled and randomized to ECC or DCC. For ECC, the umbilical cord was clamped <10s after birth; for DCC, the cord was clamped similar to 120 s after delivery. RESULTS: Thirty infants were randomized at birth. No differences between the DCC and ECC groups were observed in gestational age at birth or time of surgery. No differences were observed across all safety measures, although a trend for higher peak serum bilirubin levels (9.2 +/- 2.2 vs 7.3 +/- 3.2 mg dl(-1), P = 0.08) in the DCC group than in the ECC group was noted. Although similar at later time points, hematocrits were higher in the DCC than in the ECC infants during the first 72 h of life. The proportion of infants not receiving blood transfusions throughout hospitalization was higher in the DCC than in the ECC infants (43 vs 7%, log-rank test P = 0.02). CONCLUSION: DCC in infants with critical CHD appears both safe and feasible, with fewer infants exposed to red blood cell transfusions than with ECC. A more comprehensive appraisal of this practice is warranted.
引用
收藏
页码:826 / 831
页数:6
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