Role of Transcription Factors FoxO3 and Myogenin in Regulation of E3 Ligases MuRF-1 and MAFbx Expression in Rat Soleus at an Early Stage of Disuse Atrophy

被引：1

作者：

Mochalova, E. P. ^{[1
,2
]}

Belova, S. P. ^{[1
,2
]}

Shenkman, B. S. ^{[1
]}

Nemirovskaya, T. L. ^{[1
,2
]}

机构：

[1] Moscow Lomonosov State Univ, Fac Fundamental Med, Moscow 119992, Russia

[2] Russian Acad Sci, Inst Biomed Problems, Moscow 123007, Russia

来源：

BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY | 2019年 / 13卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

ubiquitin ligases; disuse; myogenin; MUSCLE ATROPHY;

D O I：

10.1134/S1990747818040086

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hypokinesia and gravitational unloading lead to skeletal muscle atrophy resulting from alterations in the balance between anabolic and catabolic processes. Ubiquitin proteasome system plays a significant role in the process of protein breakdown in course of disuse atrophy. E3 ligases are essential components of this system. We analyzed changes in expression of E3 ligases MuRF-1 and MAFbx, as well as transcription factors FoxO3 and myogenin in rat soleus after 1 and 3 days of hindlimb unloading. We found that expression of E3 ligases was increased after 24 h of unloading, while phosphorylation of FoxO3 (S253) was decreased. However, the expression level of myogenin increased only 3 days after unloading. Our result suggests that earlier expression of MuRF-1 and MAFbx could be regulated by FoxO3, and that myogenin can also contribute to this process on the 3rd day of unloading

引用

页码：36 / 39

页数：4

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