Novel multidimensional biomarkers for non-invasive medical diagnostics

被引：1

作者：

Vonsky, M. S. ^{[1
,2
,3
]}

Runov, A. L. ^{[1
,2
,3
]}

Moiseeva, O. M. ^{[1
]}

机构：

[1] Almazov Med Res Ctr, St Petersburg 197431, Russia

[2] DI Mendeleev Inst Metrol, St Petersburg 190005, Russia

[3] RAS, Inst Cytol, St Petersburg 194064, Russia

来源：

JOINT IMEKO TC1-TC7-TC13-TC18 SYMPOSIUM | 2019年 / 1379卷

关键词：

HOUSEKEEPING GENES; EXPRESSION; STANDARDS;

D O I：

10.1088/1742-6596/1379/1/012005

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Value of clinical laboratory diagnostics results are often underestimated in medical practice due to the fact that result of laboratory analysis in most cases represents a single biomarker of the organism homeostasis complex pathological alteration. New systemic approaches emerging on the basis of Omic's knowledge and techniques allow development of multidimensional biomarkers, reflecting multiple pathobiological axes which characterize defined pathological condition. Combination of liquid biopsy technology with multidimensional biomarkers allows to obtain clinically valuable personalized information on the patient by non-invasive approach even for hard-to-reach organs and tissues.

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页数：5

相关论文

共 16 条

[1] Normalization of real-time quantitative reverse transcription-PCR data: A model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets [J].

Andersen, CL ;

Jensen, JL ;

Orntoft, TF .

CANCER RESEARCH, 2004, 64 (15) :5245-5250

[2]

[Anonymous], 2016, BEST (Biomarkers, EndpointS, and other Tools) Resource

[3] Identification of a common gene expression signature in dilated cardiomyopathy across independent microarray studies [J].

Barth, Andreas S. ;

Kuner, Ruprecht ;

Buness, Andreas ;

Ruschhaupt, Markus ;

Merk, Sylvia ;

Zwermann, Ludwig ;

Kaeaeb, Stefan ;

Kreuzer, Eckart ;

Steinbeck, Gerhard ;

Mansmann, Ulrich ;

Poustka, Annemarie ;

Nabauer, Michael ;

Sueltmann, Holger .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (08) :1610-1617

[4] Diagnosis of myocarditis - Death of Dallas criteria [J].

Baughman, KL .

CIRCULATION, 2006, 113 (04) :593-595

[5] The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments [J].

Bustin, Stephen A. ;

Benes, Vladimir ;

Garson, Jeremy A. ;

Hellemans, Jan ;

Huggett, Jim ;

Kubista, Mikael ;

Mueller, Reinhold ;

Nolan, Tania ;

Pfaffl, Michael W. ;

Shipley, Gregory L. ;

Vandesompele, Jo ;

Wittwer, Carl T. .

CLINICAL CHEMISTRY, 2009, 55 (04) :611-622

[6]

Devonshire Alison S, 2016, Biomol Detect Quantif, V8, P15, DOI 10.1016/j.bdq.2016.05.003

[7] Microarrays coming of age in cardiovascular medicine - Standards, predictions, and biology - Editorial comment [J].

Ginsburg, Geoffrey S. ;

Seo, David ;

Frazier, Camille .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (08) :1618-1620

[8] Transcriptomic Biomarkers for the Accurate Diagnosis of Myocarditis [J].

Heidecker, Bettina ;

Kittleson, Michelle M. ;

Kasper, Edward K. ;

Wittstein, Ilan S. ;

Champion, Hunter C. ;

Russell, Stuart D. ;

Hruban, Ralph H. ;

Rodriguez, E. Rene ;

Baughman, Kenneth L. ;

Hare, Joshua M. .

CIRCULATION, 2011, 123 (11) :1174-U78

[9] Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper - Excel-based tool using pair-wise correlations [J].

Pfaffl, MW ;

Tichopad, A ;

Prgomet, C ;

Neuvians, TP .

BIOTECHNOLOGY LETTERS, 2004, 26 (06) :509-515

[10]

Runov A, 2015, CELL TISSUE BIOL, V9, P330