Excretion study of endosulfan in urine of a pest control operator

被引：19

作者：

Arrebola, FJ

Vidal, JLM ^{[1
]}

Fernández-Gutiérrez, A

机构：

[1] Univ Almeria, Dept Analyt Chem, Almeria 04071, Spain

[2] Univ Granada, Dept Analyt Chem, E-18071 Granada, Spain

来源：

TOXICOLOGY LETTERS | 1999年 / 107卷 / 1-3期

关键词：

endosulfan; human urine; excretion; occupational exposure; biological monitoring;

D O I：

10.1016/S0378-4274(99)00027-2

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A study of endosulfan excretion in human urine was carried out by using an agricultural worker involved with spraying, wearing protective overall, gloves and breathing mask. The urine samples were extracted with Solid Phase Extraction (SPE) cartridges and the compounds were separated and detected using Gas Chromatography-Tandem Mass Spectrometry (GC-MS/MS) due to their high sensitivity and selectivity in preventing most matrix interferences. The alpha- and beta-isomers of endosulfan were detected (total concentrations ranged between 5368 and 2239 pg/ml) but endosulfan-ether, -lactone or -sulphate were not found above the detection limits. The results obtained were compared with the concentrations found for a non-occupational exposed man. Statistical interpretation of the excretion-rate of the insecticide was performed by assuming that it can be described as a first-order kinetic. The constant rate and the half-lives were determined. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：15 / 20

页数：6

共 9 条

[1]

AIZAWA H, 1982, METABOLIC MAPS PESTI, P78

[2]

ASTOLFI E, 1984, ENV HLTH CRITERIA EN, P23

[3]

Cabello T., 1994, Boletin de Sanidad Vegetal, Plagas, V20, P429

[4]

FROST AA, 1961, KINETICS MECHANISM, P73

[5]

MENZIE CM, 1978, 212 US DEP INT FISH, P133

[6] THE PESTICIDES ENDOSULFAN, TOXAPHENE, AND DIELDRIN HAVE ESTROGENIC EFFECTS ON HUMAN ESTROGEN-SENSITIVE CELLS [J].

SOTO, AM ;

CHUNG, KL ;

SONNENSCHEIN, C .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1994, 102 (04) :380-383

[7] Determination of endosulfan and its metabolites in human urine using gas chromatography tandem mass spectrometry [J].

Vidal, JLM ;

Arrebola, FJ ;

Fernández-Gutiérrez, A ;

Rams, MA .

JOURNAL OF CHROMATOGRAPHY B, 1998, 719 (1-2) :71-78

[8]

*WHO, 1975, DAT SHEETS PEST, V15, P4

[9]

WORTHING CR, 1983, PESTICIDE MANUAL WOR, P233

← 1 →