Mast cells and vascular diseases

被引：21

作者：

Kennedy, Simon ^{[1
]}

Wu, Junxi ^{[2
]}

Wadsworth, Roger M. ^{[2
]}

Lawrence, Catherine E. ^{[2
]}

Maffia, Pasquale ^{[3
,4
]}

机构：

[1] Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G42 0NR, Lanark, Scotland

[3] Univ Glasgow, Coll Med Vet & Life Sci, Inst Infect Immun & Inflammat, Glasgow G12 8TA, Lanark, Scotland

[4] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy

来源：

PHARMACOLOGY & THERAPEUTICS | 2013年 / 138卷 / 01期

关键词：

Mast cell; Atherosclerosis; Restenosis; Aneurysm; Vein graft; Vascular remodeling; SERINE-PROTEASE INHIBITOR; II TYPE-1 RECEPTOR; FC-EPSILON-RI; AORTIC-ANEURYSM DEVELOPMENT; EXPERIMENTAL VEIN GRAFTS; ANGIOTENSIN-II; CHYMASE INHIBITION; CORONARY-ARTERY; INTIMAL HYPERPLASIA; NEOINTIMA FORMATION;

D O I：

10.1016/j.pharmthera.2013.01.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mast cells are increasingly being recognized as effector cells in many cardiovascular conditions. Many mast-cell-derived products such as tryptase and chymase can, through their enzymic action, have detrimental effects on blood vessel structure while mast cell-derived mediators such as cytokines and chemokines can perpetuate vascular inflammation. Mice lacking mast cells have been developed and these are providing an insight into how mast cells are involved in cardiovascular diseases and, as knowledge increase, mast cells may become a viable therapeutic target to slow progression of cardiovascular disease. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：53 / 65

页数：13

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