Synthesis and further studies of chemical transformation of the 2-aryl-3-halogenoquinolin-4(1H)-one derivatives

被引：25

作者：

Mphahlele, MJ

Nwamadi, MS

Mabeta, P

机构：

[1] Univ S Africa, Coll Sci Engn & Technol, Dept Chem, ZA-0003 Pretoria, South Africa

[2] Univ Pretoria, Dept Physiol, ZA-0001 Pretoria, South Africa

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2006年 / 43卷 / 02期

关键词：

D O I：

10.1002/jhet.5570430203

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-3 brominated and iodinated derivatives were prepared from the corresponding 2-arylquinolin-4(1H)-ones and their NMe-4-oxo derivatives using pyridinium tribromide in acetic acid or iodine-Na2CO3 mixture in THE The results of further studies of chemical transformation of the prepared alpha-haloenones and preliminary antitumour activity of the 3-bromo NH-4-oxo and NMe-4-oxo derivatives are also described.

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页码：255 / 260

页数：6

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