An atom efficient, green synthesis of 2-pyrazoline derivatives under solvent-free conditions using grinding technique

被引:27
|
作者
Zangade, Sainath B. [1 ]
Mokle, Shyam S. [1 ]
Shinde, Avinash T. [1 ]
Vibhute, Yeshwant B. [1 ]
机构
[1] Yeshwant Mahavidyalaya, Organ Synth Lab, Dept Studies Chem, Nanded 431602, MS, India
关键词
2-hydroxychalcones; 2-pyrazolines; solvent free; grinding technique; green chemistry; PYRAZOLINES; ANTIDEPRESSANT; ABSENCE;
D O I
10.1080/17518253.2012.713123
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A simple, rapid, efficient, and environmentally benign procedure for synthesis of 2-pyrazoline derivatives has been achieved by reacting 2-hydroxychalcones with hydrazine hydrate under solvent-free grinding technique. The short reaction time, cleaner reaction, easy workup, higher yields, and mild reaction conditions make this protocol practical and economically attractive in comparison with the classical reaction. [GRAPHICS] .
引用
收藏
页码:123 / 127
页数:5
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