Tabun scavengers based on hydroxamic acid containing cyclodextrins

被引：34

作者：

Brandhuber, Florian ^{[1
]}

Zengerle, Michael ^{[2
]}

Porwol, Luzian ^{[2
]}

Bierwisch, Anne ^{[1
]}

Koller, Marianne ^{[1
]}

Reiter, Georg ^{[1
]}

Worek, Franz ^{[1
]}

Kubik, Stefan ^{[2
]}

机构：

[1] Inst Pharmakol & Toxikol Bundeswehr, D-80937 Munich, Germany

[2] Tech Univ Kaiserslautern, Fachbereich Chem Organ Chem, D-67663 Kaiserslautern, Germany

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 33期

关键词：

BETA-CYCLODEXTRIN; CATALYTIC SCAVENGERS; DERIVATIVES; DETOXIFICATION; ASSAY;

D O I：

10.1039/c3cc41290c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Arrangement of several hydroxamic acid-derived substituents along the cavity of a cyclodextrin ring leads to compounds that detoxify tabun in TRIS-HCl buffer at physiological pH and 37.0 degrees C with half-times as low as 3 min.

引用

页码：3425 / 3427

页数：3

共 23 条

[1]

[Anonymous], 2007, CHEM WARFARE AGENTS, DOI DOI 10.1002/9780470060032

[2] Detoxification of tabun at physiological pH mediated by substituted β-cyclodextrin and glucose derivatives containing oxime groups [J].

Brandhuber, Florian ;

Zengerle, Michael ;

Porwol, Luzian ;

Tenberken, Oliver ;

Thiermann, Horst ;

Worek, Franz ;

Kubik, Stefan ;

Reiter, Georg .

TOXICOLOGY, 2012, 302 (2-3) :163-171

[3] Biomimetic reactions catalyzed by cyclodextrins and their derivatives [J].

Breslow, R ;

Dong, SD .

CHEMICAL REVIEWS, 1998, 98 (05) :1997-2011

[4] ACCELERATION OF THE HYDROLYSIS OF ORGANIC FLUOROPHOSPHATES AND FLUOROPHOSPHONATES WITH HYDROXAMIC ACIDS [J].

HACKLEY, BE ;

PLAPINGER, R ;

STOLBERG, M ;

WAGNERJAUREGG, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (13) :3651-3653

[5] Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers [J].

Le Provost, Romain ;

Wille, Timo ;

Louise, Ludivine ;

Masurier, Nicolas ;

Mueller, Susanne ;

Reiter, Georg ;

Renard, Pierre-Yves ;

Lafont, Olivier ;

Worek, Franz ;

Estour, Francois .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (08) :3026-3032

[6] Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: A mini review [J].

Lenz, David E. ;

Yeung, David ;

Smith, J. Richard ;

Sweeney, Richard E. ;

Lumley, Lucille A. ;

Cerasoli, Douglas M. .

TOXICOLOGY, 2007, 233 (1-3) :31-39

[7] A HTS Assay for the Detection of Organophosphorus Nerve Agent Scavengers [J].

Louise-Leriche, Ludivine ;

Paunescu, Emilia ;

Saint-Andre, Geraldine ;

Baati, Rachid ;

Romieu, Anthony ;

Wagner, Alain ;

Renard, Pierre-Yves .

CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (11) :3510-3523

[8] Cyclodextrin derivatives that display Enzyme Catalysis [J].

Marinescu, Lavinia ;

Bols, Mikael .

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 2009, 21 (122) :309-323

[9] ORGANOPHOSPHATE POISONING [J].

MARRS, TC .

PHARMACOLOGY & THERAPEUTICS, 1993, 58 (01) :51-66

[10] A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters [J].

Masson, Patrick ;

Nachon, Florian ;

Broomfield, Clarence A. ;

Lenz, David E. ;

Verdier, Laurent ;

Schopfer, Lawrence M. ;

Lockridge, Oksana .

CHEMICO-BIOLOGICAL INTERACTIONS, 2008, 175 (1-3) :273-280

← 1 2 3 →