Liquid biopsy for breast cancer using extracellular vesicles and cell-free microRNAs as biomarkers

被引：39

作者：

Murobushi Ozawa, Patricia Midori ^{[1
]}

Jucoski, Tayana Schultz ^{[1
]}

Vieira, Evelyn ^{[1
]}

Carvalho, Tamyres Mingorance ^{[1
]}

Malheiros, Danielle ^{[1
]}

De Souza Fonseca Ribeiro, Enilze Maria ^{[1
]}

机构：

[1] Univ Fed Parana, Genet Dept, Postgrad Program Genet, Curitiba, Parana, Brazil

来源：

TRANSLATIONAL RESEARCH | 2020年 / 223卷

关键词：

CIRCULATING MICRORNAS; DRUG-RESISTANCE; SERUM MICRORNA; NEOADJUVANT CHEMOTHERAPY; POTENTIAL BIOMARKER; PROGNOSTIC VALUE; EXPRESSION; EXOSOMES; PLASMA; MICROVESICLES;

D O I：

10.1016/j.trsl.2020.04.002

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Improvement of breast cancer (BC) patient's outcome is directly related to early detection. However, there is still a lack of reliable biomarkers for diagnosis, prognosis and, treatment follow up in BC, leading researchers to study the potential of liquid biopsy based on circulating microRNAs (c-miRNAs). These c-miRNAs can be cell-free or associated with extracellular vesicles (EVs), and have great advantages such as stability in biofluids, noninvasive accessibility compared to current techniques (core-biopsy and surgery), and expression associated with pathogenic conditions. Recently, a new promising field of EV-derived miRNAs (EV-miRNAs) as cancer biomarkers has emerged, receiving special attention due to their selective vesicle sorting which makes them accurate for disease detection. In this review, we discuss new findings about c-miRNA and their potential as biomarkers for BC diagnosis, prognosis, and therapy. Additionally, we address the impact of limitations associated with the standardization of analysis techniques and methods on the implementation of these biomarkers in the clinical setting.

引用

页码：40 / 60

页数：21

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