Stereoselective direct copper-catalyzed alkenylation of oxazoles with bromoalkenes

被引：123

作者：

Besselievre, Francois ^{[1
]}

Piguel, Sandrine ^{[1
]}

Mahuteau-Betzer, Florence ^{[2
]}

Grierson, David S. ^{[3
]}

机构：

[1] Univ Paris 11, F-91405 Orsay, France

[2] Ctr Univ, CNRS, UMR 176, Inst Curie, F-91405 Orsay, France

[3] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 18期

关键词：

D O I：

10.1021/ol801512q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed direct alkenylation of oxazoles with bromoalkenes has been developed. The method is both regio- and stereoselective and tolerates a variety of functional groups. A wide range of 2-E-vinyl-substituted oxazoles were obtained in high yields including the highly fluorescent alkaloid annuloline.

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页码：4029 / 4032

页数：4

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