Preparation and NMR Spectroscopic Studies of the Supramolecular Inclusion Complex of Anabasine and β-Cyclodextrin

被引：2
|
作者：
Seilkhanov, T. M. [1 ]
Nurkenov, O. A. [2 ]
Isaeva, A. Zh. [2 ]
Nazarenko, L. A. [1 ]
Seilkhanov, O. T. [1 ]
机构：
[1] Sh Ualikhanov Kokshetau State Univ, 76 Abaya St, Kokshetau 020000, Kazakhstan
[2] Inst Organ Synth & Coal Chem Republ Kazakhstan, 1 Alikhanova St, Karaganda 100008, Kazakhstan
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2016年 / 52卷 / 06期
关键词：
alkaloid anabasine; cyclodextrin; inclusion complexes; NMR spectroscopy; STABILITY; ALKALOIDS; ALPHA;
D O I：
10.1007/s10600-016-1862-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Complexation of the alkaloid anabasine by beta-cyclodextrin was studied by NMR spectroscopy. The changes of chemical shifts of H-1 and C-13 nuclei of the substrate and receptor in an inclusion complex were determined. It was found that anabasine reacted with beta-cyclodextrin to form a 1:1 stoichiometric supramolecular inclusion complex with the piperidine fragment of the substrate in the receptor inner cavity.
引用
收藏
页码：1066 / 1068
页数：3
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