Flavonoids from Iris songarica and their Antioxidant and Estrogenic Activity

被引：19
作者：
Moein, Mahmood R. [1 ,2 ,6 ]
Khan, Shabana I. [6 ]
Ali, Zulfiqar [6 ]
Ayatollahi, Syed A. M. [3 ]
Kobarfard, Farzad [3 ]
Nasim, Shama [4 ]
Choudhary, Muhammad I. [4 ]
Khan, Ikhlas A. [5 ,6 ]
机构：
[1] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Shiraz, Iran
[2] Shiraz Univ Med Sci, Sch Pharm, Pharmaceut Sci Res Ctr, Shiraz, Iran
[3] Shahid Beheshti Univ Med Sci, Sch Pharm, Tehran, Iran
[4] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi, Pakistan
[5] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Dept Pharmacognosy, University, MS 38677 USA
[6] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA
来源：
PLANTA MEDICA | 2008年 / 74卷 / 12期
关键词：
Iris songarica; Iridaceae; songaricol; flavonoids; antioxidant; estrogenic;
D O I：
10.1055/s-2008-1081342
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new dihydroflavonol, songaricol (1) and seven known flavonoids, ayamenin A (2), irisflavone A (3), 5,7-dihydroxy-2',6-dimethoxyisoflavone (4), irilin B (5), 5,3'-dihydroxy-7,8,2'-trimethoxyisoflavone (6) and irisoid A (7) were isolated from rhizome and roots of Iris songarica. Structure elucidation of 1 was achieved through extensive NMR and circular dichroism techniques. Compounds 1, 5 and 7 showed antioxidant activity in HL-60 cells (IC50 values of 21, 11 and 3.8 mu g/mL), whereas 2, 5 and the previously isolated irisone B were able to show estrogenic response (EC50 values of 305.5, 159.7 and 322.0 mu g/mL) in yeast cells expressing human estrogen receptor (ER-alpha).
引用
收藏
页码：1492 / 1495
页数：4
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