Flavonoids from Iris songarica and their Antioxidant and Estrogenic Activity

被引：19

作者：

Moein, Mahmood R. ^{[1
,2
,6
]}

Khan, Shabana I. ^{[6
]}

Ali, Zulfiqar ^{[6
]}

Ayatollahi, Syed A. M. ^{[3
]}

Kobarfard, Farzad ^{[3
]}

Nasim, Shama ^{[4
]}

Choudhary, Muhammad I. ^{[4
]}

Khan, Ikhlas A. ^{[5
,6
]}

机构：

[1] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Shiraz, Iran

[2] Shiraz Univ Med Sci, Sch Pharm, Pharmaceut Sci Res Ctr, Shiraz, Iran

[3] Shahid Beheshti Univ Med Sci, Sch Pharm, Tehran, Iran

[4] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi, Pakistan

[5] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Dept Pharmacognosy, University, MS 38677 USA

[6] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

来源：

PLANTA MEDICA | 2008年 / 74卷 / 12期

关键词：

Iris songarica; Iridaceae; songaricol; flavonoids; antioxidant; estrogenic;

D O I：

10.1055/s-2008-1081342

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new dihydroflavonol, songaricol (1) and seven known flavonoids, ayamenin A (2), irisflavone A (3), 5,7-dihydroxy-2',6-dimethoxyisoflavone (4), irilin B (5), 5,3'-dihydroxy-7,8,2'-trimethoxyisoflavone (6) and irisoid A (7) were isolated from rhizome and roots of Iris songarica. Structure elucidation of 1 was achieved through extensive NMR and circular dichroism techniques. Compounds 1, 5 and 7 showed antioxidant activity in HL-60 cells (IC50 values of 21, 11 and 3.8 mu g/mL), whereas 2, 5 and the previously isolated irisone B were able to show estrogenic response (EC50 values of 305.5, 159.7 and 322.0 mu g/mL) in yeast cells expressing human estrogen receptor (ER-alpha).

引用

页码：1492 / 1495

页数：4

共 50 条

[11] Novel flavonoids with antioxidant activity from a Chenopodiaceous plant
Awaad, Amani S.
Maitland, D. J.
Donia, Abd El Raheim M.
Alqasoumi, Saleh I.
Soliman, Gamal A.
[J]. PHARMACEUTICAL BIOLOGY, 2012, 50 (01) : 99 - 104
[12] Antioxidant activity of flavonoids isolated from Scutellaria rehderiana
Su, YL
Leung, LK
Bi, YR
Huang, Y
Chen, ZY
[J]. JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 2000, 77 (08) : 807 - 812
[13] Antioxidant activity of flavonoids isolated from Hypericum ternum
Bernardi, A. P. M.
Lopez-Alarcon, C.
Aspee, A.
Rech, S.
Von Poser, G. L.
Bridi, R.
Lissi, E.
[J]. JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2007, 52 (04): : 1326 - 1329
[14] Characterisation of the antioxidant activity of flavonoids
Masuoka, Noriyoshi
Matsuda, Maya
Kubo, Isao
[J]. FOOD CHEMISTRY, 2012, 131 (02) : 541 - 545
[15] Estrogenic flavonoids from Artemisia vulgaris L
Lee, SJ
Chung, HY
Maier, CGA
Wood, AR
Dixon, RA
Mabry, TJ
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1998, 46 (08) : 3325 - 3329
[16] A theoretical study on cellular antioxidant activity of selected flavonoids
Rong, Yuzhi
Wang, Zhengwu
Wu, Jinhong
Zhao, Bo
[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2012, 93 : 235 - 239
[17] Flavonoids of the Genus Iris (Iridaceae)
Wang, Hui
Cui, Yanmei
Zhao, Changqi
[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2010, 10 (07) : 643 - 661
[18] A Study on Extraction and Antioxidant Activity of Flavonoids from Wolfberry and Hawthorn
Bian, Lihong
Zhai, Zuhuan
Zhang, Lixia
Zhang, Zhiguo
[J]. 2016 ISSGBM INTERNATIONAL CONFERENCE ON INFORMATION, COMMUNICATION AND SOCIAL SCIENCES (ISSGBM-ICS 2016), PT 4, 2016, 69 : 321 - 325
[19] Structure-activity relationships of flavonoids in the cellular antioxidant activity assay
Wolfe, Kelly L.
Liu, Rui Hai
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (18) : 8404 - 8411
[20] Antioxidant Activity of Flavonoids from Sweet Potato Vines in Vitro
Li, Ying Chang
[J]. APPLICATION OF CHEMICAL ENGINEERING, PTS 1-3, 2011, 236-238 : 2634 - 2638

← 1 2 3 4 5 →