A BODIPY-based fluorescent dye for mitochondria in living cells, with low cytotoxicity and high photostability

被引：106

作者：

Zhang, Si ^{[2
]}

Wu, Tong ^{[2
]}

Fan, Jiangli ^{[2
]}

Li, Zhiyong ^{[2
]}

Jiang, Na ^{[2
]}

Wang, Jingyun ^{[1
]}

Dou, Bairui ^{[1
]}

Sun, Shiguo ^{[2
]}

Song, Fengling ^{[2
]}

Peng, Xiaojun ^{[2
]}

机构：

[1] Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China

[2] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 04期

基金：

美国国家科学基金会; 中央高校基本科研业务费专项资金资助;

关键词：

MOLECULAR PROBES; SELECTIVITY; SENSOR;

D O I：

10.1039/c2ob26911b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A BODIPY-based dye, OBEP, has been developed to act as a mitochondrial fluorescence probe. This dye is of high stability, low toxicity and insensitive in a pH range as wide as pH 2-10. Its uptake into mitochondria is independent of mitochondrial membrane potential in living cells. OBEP can label swollen mitochondria resulting from different degrees of cell damage in light and resist fading even after 12 h of incubation.

引用

页码：555 / 558

页数：4

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