Tuberculosis

被引:78
作者
Ankrah, Alfred O. [1 ,2 ,3 ]
Glaudemans, Andor W. J. M. [4 ]
Maes, Alex [1 ,2 ,4 ,5 ]
Van de Wiele, Christophe [1 ,2 ,6 ]
Dierckx, Rudi A. J. O. [3 ]
Vorster, Mariza [1 ,2 ]
Sathekge, Mike M. [1 ,2 ]
机构
[1] Univ Pretoria, Dept Nucl Med, Private Bag X169, ZA-0001 Pretoria, South Africa
[2] Steve Biko Acad Hosp, Private Bag X169, ZA-0001 Pretoria, South Africa
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands
[4] AZ Groeninge, Dept Nucl Med, Kortrijk, Belgium
[5] Univ Hosp Leuven, Dept Morphol & Med Imaging, Leuven, Belgium
[6] Univ Ghent, Dept Nucl Med & Radiol, Ghent, Belgium
关键词
EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY; SOLITARY PULMONARY NODULES; HIV-ASSOCIATED LYMPHOMA; QUANTITATIVE FDG-PET; POSITRON-EMISSION; F-18-FDG PET/CT; REACTIVATION TUBERCULOSIS; HEPATIC TUBERCULOSIS; MULTIDRUG-RESISTANT; NUCLEAR-MEDICINE;
D O I
10.1053/j.semnuclmed.2017.10.005
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Tuberculosis (TB) is currently the world's leading cause of infectious mortality. Imaging plays an important role in the management of this disease. The complex immune response of the human body to Mycobacterium tuberculosis results in a wide array of clinical manifestations, making clinical and radiological diagnosis challenging. F-18-FDG-PET/CT is very sensitive in the early detection of TB in most parts of the body; however, the lack of specificity is a major limitation. F-18-FDG-PET/CT images the whole body and provides a pre-therapeutic metabolic map of the infection, enabling clinicians to accurately assess the burden of disease. It enables the most appropriate site of biopsy to be selected, stages the infection, and detects disease in previously unknown sites.F-18-FDG-PET/CT has recently been shown to be able to identify a subset of patients with latent TB infection who have subclinical disease. Lung inflammation as detected by F-18-FDG-PET/CT has shown promising signs that it may be a useful predictor of progression from latent to active infection. A number of studies have identified imaging features that might improve the specificity of F-18-FDG-PET/CT at some sites of extrapulmonary TB. Other PET tracers have also been investigated for their use in TB, with some promising results. The potential role and future perspectives of PET/CT in imaging TB is considered. Literature abounds on the very important role of F-18-FDG-PET/CT in assessing therapy response in TB. The use of F-18-FDG for monitoring response to treatment is addressed in a separate review. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码:108 / 130
页数:23
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