Targeting epitopes in prostate-specific membrane antigen for antibody therapy of prostate cancer

被引：10
|
作者：
Kinoshita, Y
Kuratsukuri, K
Newman, N
Rovito, PM
Kaumaya, PTP
Wang, CY
Haas, GP
机构：
[1] SUNY Upstate Med Ctr, Dept Urol, Syracuse, NY 13210 USA
[2] SUNY Upstate Med Ctr, Dept Med, Syracuse, NY 13210 USA
[3] Ohio State Univ, Dept Obstet & Gynecol, Columbus, OH 43210 USA
[4] VA Med Ctr, Syracuse, NY USA
来源：
PROSTATE CANCER AND PROSTATIC DISEASES | 2005年 / 8卷 / 04期
关键词：
antibody; prostate-specific membrane antigen; LNCaP; prostate cancer; antitumor activity; glutamate carboxypeptidase;
D O I：
10.1038/sj.pcan.4500835
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate-specific membrane antigen ( PSMA) is a target for immunotherapy of prostate cancer. It has been shown that antibodies against PSMA inhibited the in vivo growth of LNCaP tumor. In the present study, monoclonal antibodies against four epitopes in PSMA were raised. MAb 24.4E6 (IgG1), specific for the epitope ( residues 638 - 657) in PSMA, significantly reduced the growth rate of established LNCaP tumor in SCID mice. Mouse IgG was detected in the tumor of mice treated with 24.4E6, but not with an unrelated MAb. These results suggest that this epitope may be the main target in PSMA for antibody therapy of prostate cancer.
引用
收藏
页码：359 / 363
页数：5
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