Fate of 130 hemagglutinins from different influenza A viruses

被引：20
|
作者：
Wu, G [1 ]
Yan, SM [1 ]
机构：
[1] DreamSciTech Consulting Co Ltd, Shenzhou 518054, Guangdong Prov, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 317卷 / 03期
关键词：
amino acid pair; hemagglutinin; influenza A virus; probability;
D O I：
10.1016/j.bbrc.2004.03.134
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study. We use our probabilistic models to analyze 130 hemagglutinins from different influenza A virus in order to gain the insight into their fate. The results provide three lines of evidence regarding the H5, H6 and H9 hemagglutinins: (i) the H5 hemagglutinins are more sensitive to mutations, this is the current state of the H5, H6, and H9 hemagglutinins: (ii) the H5 hemagglutinins had experienced more mutations in the past, this is the history of the H5, H6, and H9 hemagglutinins; and (iii) the H6 hemagglutinins has a bigger potential towards future mutations. this is the future of the H5, H6, and H9 hemagglutinins. Furthermore. this study gives two clues oil the mutation tendency that is a degeneration process and the species Susceptibility that is the chickens and clucks. (C) 2004 Elsevier Ire. All rights reserved.
引用
收藏
页码：917 / 924
页数：8
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