Myristicyclins A and B: Antimalarial Procyanidins from Horsfieldia spicata from Papua New Guinea

被引：18

作者：

Lu, Zhenyu ^{[1
]}

Van Wagoner, Ryan M. ^{[1
]}

Pond, Cristopher D. ^{[2
,3
]}

Pole, Ann R. ^{[2
,3
]}

Jensen, James B. ^{[2
,3
]}

Blankenship, D'Arbra ^{[4
]}

Grimberg, Brian T. ^{[4
]}

Kiapranis, Robert ^{[5
]}

Matainaho, Teatulohi K. ^{[6
]}

Barrows, Louis R. ^{[2
,3
]}

Ireland, Chris M. ^{[1
]}

机构：

[1] Univ Utah, Coll Pharm, Dept Med Chem, Salt Lake City, UT 84112 USA

[2] Univ Utah, Coll Pharm, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA

[3] Univ Utah, LS Skaggs Pharm Inst, Salt Lake City, UT 84112 USA

[4] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA

[5] Papua New Guinea Forest Res Inst, Lae, Papua N Guinea

[6] Univ Papua New Guinea, NCD, Port Moresby, Papua N Guinea

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 02期

关键词：

A-TYPE PROANTHOCYANIDINS; PLASMODIUM-FALCIPARUM; SIGNALING PATHWAYS; MEDICINAL-PLANTS; DRUG DISCOVERY; FLOW-CYTOMETRY; CANCER-CELLS; CRANBERRY; LIGNAN; IDENTIFICATION;

D O I：

10.1021/ol4022639

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An antimalarial screen for plants collected from Papua New Guinea identified an extract of Horsfieldia spicata as having activity. Isolation of the active constituents led to the identification of two new compounds: myristicyclins A (1) and B (2). Both compounds are procyanidin-like congeners of myristinins lacking a pendant aromatic ring. Myristicyclin A was found to inhibit the ring, trophozoite, and schizont stages of Plasmodium falciparum at similar concentrations in the mid-mu M range.

引用

页码：346 / 349

页数：4

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