Genetics and alcoholism

被引：117
作者：
Edenberg, Howard J. [1 ]
Foroud, Tatiana [2 ]
机构：
[1] Indiana Univ, Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA
来源：
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2013年 / 10卷 / 08期
基金：
美国国家卫生研究院;
关键词：
GENOME-WIDE ASSOCIATION; CROSS-FOSTERING ANALYSIS; LINKAGE DISEQUILIBRIUM; DRUG-DEPENDENCE; DSM-IV; ENVIRONMENTAL CONTRIBUTIONS; CHRM2; GENE; GABRA2; RISK; DEHYDROGENASE;
D O I：
10.1038/nrgastro.2013.86
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Alcohol is widely consumed; however, excessive use creates serious physical, psychological and social problems and contributes to the pathogenesis of many diseases. Alcohol use disorders (that is, alcohol dependence and alcohol abuse) are maladaptive patterns of excessive drinking that lead to serious problems. Abundant evidence indicates that alcohol dependence (alcoholism) is a complex genetic disease, with variations in a large number of genes affecting a person's risk of alcoholism. Some of these genes have been identified, including two genes involved in the metabolism of alcohol (ADH1B and ALDH2) that have the strongest known affects on the risk of alcoholism. Studies continue to reveal other genes in which variants affect the risk of alcoholism or related traits, including GABRA2, CHRM2, KCNJ6 and AUTS2. As more variants are analysed and studies are combined for meta-analysis to achieve increased sample sizes, an improved picture of the many genes and pathways that affect the risk of alcoholism will be possible.
引用
收藏
页码：487 / 494
页数：8
相关论文
共 91 条
  • [1] Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample
    Agrawal, Arpana
    Edenberg, Howard J.
    Foroud, Tatiana
    Bierut, Laura J.
    Dunne, Gerald
    Hinrichs, Anthony L.
    Nurnberger, John I.
    Crowe, Raymond
    Kuperman, Samuel
    Schuckit, Marc A.
    Begleiter, Henri
    Porjesz, Bernice
    Dick, Danielle M.
    [J]. BEHAVIOR GENETICS, 2006, 36 (05) : 640 - 650
  • [2] DSM-IV to DSM-5: the impact of proposed revisions on diagnosis of alcohol use disorders
    Agrawal, Arpana
    Heath, Andrew C.
    Lynskey, Michael T.
    [J]. ADDICTION, 2011, 106 (11) : 1935 - 1943
  • [3] [Anonymous], 2011, DIET GUID AM 2010, V7th
  • [4] [Anonymous], 2022, Deaths from Noncommunicable Diseases on the Rise in Africa Africa
  • [5] [Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787
  • [6] EEG, AUTONOMIC AND SUBJECTIVE CORRELATES OF THE RISK FOR ALCOHOLISM
    BAUER, LO
    HESSELBROCK, VM
    [J]. JOURNAL OF STUDIES ON ALCOHOL, 1993, 54 (05): : 577 - 589
  • [7] Quantitative trait loci analysis of human event-related brain potentials: P3 voltage
    Begleiter, H
    Porjesz, B
    Reich, T
    Edenberg, HJ
    Goate, A
    Blangero, J
    Almasy, L
    Foroud, T
    Van Eerdewegh, P
    Polich, J
    Rohrbaugh, J
    Kuperman, S
    Bauer, LO
    O'Connor, SJ
    Chorlian, DB
    Li, TK
    Conneally, PM
    Hesselbrock, V
    Rice, JP
    Schuckit, MA
    Cloninger, R
    Nurnberger, J
    Crowe, R
    Bloom, FE
    [J]. EVOKED POTENTIALS-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1998, 108 (03): : 244 - 250
  • [8] ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry
    Bierut, L. J.
    Goate, A. M.
    Breslau, N.
    Johnson, E. O.
    Bertelsen, S.
    Fox, L.
    Agrawal, A.
    Bucholz, K. K.
    Grucza, R.
    Hesselbrock, V.
    Kramer, J.
    Kuperman, S.
    Nurnberger, J.
    Porjesz, B.
    Saccone, N. L.
    Schuckit, M.
    Tischfield, J.
    Wang, J. C.
    Foroud, T.
    Rice, J. P.
    Edenberg, H. J.
    [J]. MOLECULAR PSYCHIATRY, 2012, 17 (04) : 445 - 450
  • [9] Blednov YA, 2001, J PHARMACOL EXP THER, V298, P521
  • [10] BOHMAN M, 1981, ARCH GEN PSYCHIAT, V38, P965
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