LINE-1 retrotransposons in healthy and diseased human brain

被引：55

作者：

Suarez, Nicole A. ^{[1
]}

Macia, Angela ^{[1
]}

Muotri, Alysson R. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, Rady Childrens Hosp San Diego, La Jolla, CA 92093 USA

来源：

DEVELOPMENTAL NEUROBIOLOGY | 2018年 / 78卷 / 05期

基金：

美国国家卫生研究院;

关键词：

LINE-1; retrotransposition; brain; neurological disorders; autism; AICARDI-GOUTIERES-SYNDROME; MAJOR DEPRESSIVE DISORDER; COPY-NUMBER VARIATION; EMBRYONIC STEM-CELLS; 22Q11.2 DELETION SYNDROME; AUTISM SPECTRUM DISORDER; CARDIO-FACIAL SYNDROME; POSTTRAUMATIC-STRESS-DISORDER; HUMAN L1 RETROTRANSPOSITION; HUMAN TRANSPOSABLE ELEMENT;

D O I：

10.1002/dneu.22567

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long interspersed element-1 (LINE-1 or L1) is a transposable element with the ability to self-mobilize throughout the human genome. The L1 elements found in the human brain is hypothesized to date back 56 million years ago and has survived evolution, currently accounting for 17% of the human genome. L1 retrotransposition has been theorized to contribute to somatic mosaicism. This review focuses on the presence of L1 in the healthy and diseased human brain, such as in autism spectrum disorders. Throughout this exploration, we will discuss the impact L1 has on neurological disorders that can occur throughout the human lifetime. With this, we hope to better understand the complex role of L1 in the human brain development and its implications to human cognition. (c) 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 434-455, 2018

引用

页码：434 / 455

页数：22

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