Skin barrier in atopic dermatitis

被引：78

作者：

Kezic, Sanja ^{[1
]}

Novak, Natalija ^{[2
]}

Jakasa, Ivone ^{[3
]}

Jungersted, Jakob M. ^{[4
]}

Simon, Michel ^{[5
]}

Brandner, Johanna M. ^{[6
]}

Middelkamp-Hup, Maritza A. ^{[7
]}

Weidinger, Stephan ^{[8
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Coronel Inst Occupat Hlth, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands

[2] Dept Dermatol & Allergy, D-53105 Bonn, Germany

[3] Univ Zagreb, Fac Food Technol & Biotechnol, Dept Chem & Biochem, Analyt Chem Lab, Zagreb 10000, Croatia

[4] Univ Copenhagen, Roskilde Hosp, Dept Dermatol, DK-4000 Roskilde, Denmark

[5] Univ Toulouse, CHU Purpan, CNRS, INSERM,UMR5165, F-31059 Toulouse 9, France

[6] Univ Hosp Hamburg Eppendorf, Dept Dermatol & Venerol, D-20246 Hamburg, Germany

[7] Univ Amsterdam, Acad Med Ctr, Dept Dermatol, NL-1100 DE Amsterdam, Netherlands

[8] Univ Hosp Schleswig Holstein, Dept Dermatol Allergol & Venerol, D-24105 Kiel, Germany

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2014年 / 19卷

关键词：

Atopic dermatitis; Skin Barrier; Genetics; Immunology; Review; TIGHT JUNCTION PROTEINS; OF-FUNCTION MUTATIONS; EPIDERMAL DIFFERENTIATION COMPLEX; NATURAL MOISTURIZING FACTOR; TRANSEPIDERMAL WATER-LOSS; STRATUM-CORNEUM BARRIER; GENOME-WIDE ASSOCIATION; ALLERGY CLIN IMMUNOL; N-ACYL LINKAGE; UROCANIC ACID;

D O I：

10.2741/4225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a number of skin diseases, in particular atopic dermatitis (AD). This review summarizes current knowledge on the role of the skin barrier in AD with regard to pathogenesis and treatment, on the relationship between skin barrier abnormalities and immune aberrations, and on potential therapies aimed at repair of the skin barrier. Furthermore recent advances in the genetics of AD will be addressed.

引用

页码：541 / 556

页数：16

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