THERMAL CHARACTERIZATION OF INDINAVIR SULFATE USING TG, DSC AND DSC-PHOTOVISUAL

被引：16

作者：

Ferreira da Silva, Rosali Maria ^{[1
]}

Morais de Medeiros, Flavia Patricia ^{[1
,4
]}

Nascimento, T. G. ^{[2
]}

Macedo, R. O. ^{[3
]}

Neto, P. J. R. ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Dept Ciencias Farmaceut, Lab Tecnol Medicamentos, Recife, PE, Brazil

[2] Univ Fed Alagoas UFAL, Escola Enfermagem & Farm, Lab Controle Qualidade Farmacos & Medicamentos, Maceio, Alagoas, Brazil

[3] Univ Fed Paraiba UFPB, Dept Ciencias Farmaceut, Lab Unificados Desenvolvimento Medicamentos & Ens, BR-58059900 Joao Pessoa, Paraiba, Brazil

[4] Lab Farmaceut Estado Pernambuco LAFEPE, Recife, PE, Brazil

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2009年 / 95卷 / 03期

关键词：

DSC-photovisual; indinavir sulfate; pseudo-polymorphism; quality control; TG; SYSTEM; TABLETS; STABILITY;

D O I：

10.1007/s10973-008-8912-7

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The object of the present work is to study the thermal characteristics of indinavir sulfate and to evaluate the quality of the raw materials. Indinavir A, B, C and reference samples were obtained from different suppliers and submitted to TG, DSC and DSC-photovisual analyses. TG/DTG curves indicated a desolvation and dehydration processes and were confirmed by DSC. According to the DSC curves the fusion took place at about 141-142 degrees C for indinavir C and Reference sample B and about 146-149 degrees C for the others. DSC-photovisual showed insoluble raw materials for indinavir C at 160 degrees C. Indinavir sulfate is highly hygroscopic drug which requires attention during storage and manufacture by pharmaceutical industry.

引用

页码：965 / 968

页数：4

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