A New Macrodiolide and Two New Polycyclic Chromones from the Fungus Penicillium sp. SCSIO041218

被引：11

作者：

Huang, Jingxia ^{[1
]}

She, Jianglian ^{[2
]}

Yang, Xiliang ^{[2
]}

Liu, Juan ^{[3
]}

Zhou, Xuefeng ^{[3
]}

Yang, Bin ^{[3
]}

机构：

[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China

[2] Wuhan Univ Sci Technol, Inst Infect Immunol & Tumor Microenvironm, Hubei Prov Key Lab Occupat Hazard Identificat & C, Dept Pharm,Med Coll, Wuhan 430081, Hubei, Peoples R China

[3] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 09期

基金：

中国国家自然科学基金;

关键词：

marine fungus; Penicillium sp; penixanthone; macrodiolide; chromone; PRENYLATED INDOLE ALKALOIDS; TALAROMYCES-FLAVUS; METABOLITES; BIOSYNTHESIS; DERIVATIVES;

D O I：

10.3390/molecules24091686

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new macrodiolide, mangrovlide A (1) and two new polycyclic chromones, penixanthones C (2) and D (3), as well as four other known compounds (4-7), have been isolated from the mangrove sediment derived fungus Penicillium sp. SCSIO041218, cultured in the 0.25% NaCl rice substrate. The structures of the new compounds were determined by analysis of the NMR and MS spectroscopic data. Compound 1 possesses a 10-membered macrodiolide unit, while 2 and 3 are chromones with an unprecedented 6/6/6/5 polycyclic skeleton. Compounds 1-7 were evaluated for their cytotoxicities, while all the compounds displayed weak or no activity.

引用

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