Myeloid derived-suppressor cells: their role in cancer and obesity

被引：92

作者：

Strand-Rosenberg, Suzanne ^{[1
,2
,3
]}

机构：

[1] Univ Maryland Baltimore Cty, Dept Biol Sci, 1000 Hilltop Circle, Baltimore, MD 21250 USA

[2] Univ Utah, Dept Pathol, Salt Lake City, UT 84112 USA

[3] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2018年 / 51卷

基金：

美国国家卫生研究院;

关键词：

HIGH-FAT DIET; TUMOR PROGRESSION; CHRONIC INFLAMMATION; IMMUNE-RESPONSE; LEPTIN; PROMOTE; DIFFERENTIATION; PROLIFERATION; ACTIVATION; MECHANISMS;

D O I：

10.1016/j.coi.2018.03.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid-derived suppressor cells (MDSC) are present in most individuals with cancer where they inhibit adaptive and innate antitumor immunity and are an obstacle to cancer immunotherapies. Chronic inflammation is characteristic of adipose tissue and is a risk factor for the onset and progression of cancer in obese individuals. Because MDSC accumulate in response to inflammation, it has been hypothesized that one of the mechanisms by which obesity promotes malignancy is through the induction of MDSC. This article reviews the data supporting this hypothesis, the role of leptin and fatty acid metabolism in the induction of MDSC, and the surprising finding that although MDSC promote tumor progression, they are protective against some of the metabolic dysfunction associated with obesity.

引用

页码：68 / 75

页数：8

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