Sarcomatoid renal cell carcinoma: Biology and treatment advances

被引：48
作者：
El Mouallem, Nemer [1 ]
Smith, Steven C. [2 ]
Paul, Asit K. [1 ]
机构：
[1] Virginia Commonwealth Univ, Div Hematol Oncol & Palliat Care, Massey Canc Ctr, VCU Med Ctr, Richmond, VA 23284 USA
[2] Virginia Commonwealth Univ, Dept Pathol, Massey Canc Ctr, VCU Med Ctr, Richmond, VA USA
来源：
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2018年 / 36卷 / 06期
关键词：
Sarcomatoid renal cell carcinoma; Renal cell carcinoma; Nephrectomy; Chemotherapy; Targeted therapy; Immunotherapy; CYTOREDUCTIVE NEPHRECTOMY; INTERNATIONAL SOCIETY; ANTI-PD-L1; ANTIBODY; PD-L1; EXPRESSION; CANCER; TUMORS; CLASSIFICATION; PATHOLOGY; BIOPSY; SAFETY;
D O I：
10.1016/j.urolonc.2017.12.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sarcomatoid transformation in renal cell carcinoma, so called sacromatoid RCC (sRCC), is associated with an aggressive behavior and a poor prognosis. Current therapeutic approaches are largely ineffective. Recent studies looking into the genomic and molecular characterization of sRCCs have provided insights into the biology and pathogenesis of this entity. These advances in molecular signatures may help development of effective treatment strategies. We herein present a review of recent developments in the pathology, biology, and treatment modalities in sRCC. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：265 / 271
页数：7
相关论文
共 50 条
  • [41] Real-life experience of patients with sarcomatoid renal cell carcinoma: a multicenter retrospective study
    Almuradova, Elvina
    Basoglu, Tugba
    Nayir, Erdinc
    Bayram, Ertugrul
    Paydas, Semra
    Gokmen, Ivo
    Karakaya, Serdar
    Oksuzoglu, Berna
    Erdem, Dilek
    Sakin, Abdullah
    Atci, Mustafa
    Gulbagci, Burcu Belen
    Hacibekiroglu, Ilhan
    Onder, Arif Hakan
    Karaarslan, Serap
    Eryilmaz, Melek Karakurt
    Korkmaz, Mustafa
    Yazici, Ozan
    Sutcuoglu, Osman
    Akagunduz, Baran
    Arak, Haci
    Sakalar, Teoman
    Aydin, Dincer
    Iriagac, Yakup
    Alan, Ozkan
    Midik, Murat
    Cetin, Denis
    Kip, Asli Dilara
    Turhal, Serdar
    Kacan, Turgut
    Koseci, Tolga
    NEOPLASMA, 2023, 70 (01) : 158 - 165
  • [42] Histologic Evaluation of Metastases in Renal Cell Carcinoma With Sarcomatoid Transformation and Its Implications for Systemic Therapy
    Shuch, Brian
    Said, Jonathan
    LaRochelle, Jeffrey C.
    Zhou, Ying
    Li, Gang
    Klatte, Tobias
    Pouliot, Frederic
    Kabbinavar, Fairooz F.
    Belldegrun, Arie S.
    Pantuck, Allan J.
    CANCER, 2010, 116 (03) : 616 - 624
  • [43] Sarcomatoid renal cell carcinoma with scant carcinomatous components
    Koga, F
    Kawano, K
    Honda, M
    Sumi, S
    Horimi, H
    Kondo, S
    Yoshida, K
    INTERNATIONAL JOURNAL OF UROLOGY, 2000, 7 (02) : 58 - 60
  • [44] Colonic Metastasis of Renal Cell Carcinoma with Sarcomatoid Differentiation
    D'Sa, Bouvier Francis Valere
    Haider, Nazima
    Fatima, Sohaila
    JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2019, 13 (01) : ED5 - ED7
  • [45] Balancing treatment efficacy, toxicity and complication risk in elderly patients with metastatic renal cell carcinoma
    van den Brom, R. R. H.
    van Es, S. C.
    Leliveld, A. M.
    Gietema, J. A.
    Hospers, G. A. P.
    de Jong, I. J.
    de Vries, E. G. E.
    Oosting, S. F.
    CANCER TREATMENT REVIEWS, 2016, 46 : 63 - 72
  • [46] A giant sarcomatoid renal cell carcinoma
    Wu, Mei-Yi
    Liaw, Chuang-Chi
    Chen, Yung-Chang
    Tian, Ya-Chung
    Hsueh, Swei
    Jenq, Chang-Chyi
    Fang, Ji-Tseng
    Yang, Chin-Wei
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 (03) : 952 - 953
  • [47] Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm
    Raychaudhuri, Ruben
    Riese, Matthew J.
    Bylow, Kathryn
    Burfeind, John
    Mackinnon, Alexander C.
    Tolat, Parag P.
    Iczkowski, Kenneth A.
    Kilari, Deepak
    CLINICAL GENITOURINARY CANCER, 2017, 15 (05) : E897 - E901
  • [48] Sarcomatoid-variant Renal Cell Carcinoma Treatment Outcome and Survival in Advanced Disease
    Molina, Ana M.
    Tickoo, Satish K.
    Ishill, Nicole
    Trinos, Michael J.
    Schwartz, Lawrence H.
    Patil, Sujata
    Feldman, Darren R.
    Reuter, Victor E.
    Russo, Paul
    Motzer, Robert J.
    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2011, 34 (05): : 454 - 459
  • [49] Combined Clear Cell Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma: A Case Report
    Meliti, Abdelrazak
    Alardati, Hosam
    Khayat, Manal
    Alruqi, Abdullah
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (06)
  • [50] Magnetic resonance imaging (MRI) helps differentiate renal cell carcinoma with sarcomatoid differentiation from renal cell carcinoma without sarcomatoid differentiation
    Mitsuru Takeuchi
    Adam T. Froemming
    Akira Kawashima
    Prabin Thapa
    Rickey E. Carter
    John C. Cheville
    R. Houston Thompson
    Naoki Takahashi
    Abdominal Radiology, 2022, 47 : 2168 - 2177
12345