Sarcomatoid renal cell carcinoma: Biology and treatment advances

被引：48
作者：
El Mouallem, Nemer [1 ]
Smith, Steven C. [2 ]
Paul, Asit K. [1 ]
机构：
[1] Virginia Commonwealth Univ, Div Hematol Oncol & Palliat Care, Massey Canc Ctr, VCU Med Ctr, Richmond, VA 23284 USA
[2] Virginia Commonwealth Univ, Dept Pathol, Massey Canc Ctr, VCU Med Ctr, Richmond, VA USA
来源：
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2018年 / 36卷 / 06期
关键词：
Sarcomatoid renal cell carcinoma; Renal cell carcinoma; Nephrectomy; Chemotherapy; Targeted therapy; Immunotherapy; CYTOREDUCTIVE NEPHRECTOMY; INTERNATIONAL SOCIETY; ANTI-PD-L1; ANTIBODY; PD-L1; EXPRESSION; CANCER; TUMORS; CLASSIFICATION; PATHOLOGY; BIOPSY; SAFETY;
D O I：
10.1016/j.urolonc.2017.12.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sarcomatoid transformation in renal cell carcinoma, so called sacromatoid RCC (sRCC), is associated with an aggressive behavior and a poor prognosis. Current therapeutic approaches are largely ineffective. Recent studies looking into the genomic and molecular characterization of sRCCs have provided insights into the biology and pathogenesis of this entity. These advances in molecular signatures may help development of effective treatment strategies. We herein present a review of recent developments in the pathology, biology, and treatment modalities in sRCC. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：265 / 271
页数：7
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