miR-186, a serum microRNA, induces endothelial cell apoptosis by targeting SMAD6 in Kawasaki disease

被引：37

作者：

Wu, Rongzhou ^{[1
,2
]}

Shen, Danping ^{[1
,2
]}

Sohun, Hareshwaree ^{[1
,2
]}

Ge, Donghui ^{[1
,2
]}

Chen, Xianda ^{[1
,2
]}

Wang, Xuliang ^{[1
,2
]}

Chen, Ruiyao ^{[1
,2
]}

Wu, Yuqing ^{[3
]}

Zeng, Jingjing ^{[1
,2
]}

Rong, Xing ^{[1
,2
]}

Su, Xiaoping ^{[1
,2
]}

Chu, Maoping ^{[1
,2
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Childrens Heart Ctr, Inst Cardiovasc Dev & Translat Med, 105 Xueyuan Rd, Wenzhou 325027, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Yuying Childrens Hosp, 105 Xueyuan Rd, Wenzhou 325027, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Wenzhou 325035, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2018年 / 41卷 / 04期

关键词：

Kawasaki disease; microRNA; miR-186; endothelial cell; mitogen-activated protein kinase pathway; SMAD family member 6; TGF-BETA; ACTIVATION; PROLIFERATION; DIAGNOSIS; CHILDREN; ATHEROSCLEROSIS; DYSFUNCTION; EXPRESSION; BIOMARKERS; ADULTHOOD;

D O I：

10.3892/ijmm.2018.3397

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Kawasaki disease (KD) is an acute, self-limited vasculitis that predominantly affects medium-sized arteries, particularly the coronary arteries. Recent studies have indicated that microRNAs are involved in many diseases, including KD. However, the detailed mechanism remains unclear. The aim of the present study was to explore the role of miR-186 in KD and potentially discover a new target for KD treatment. The results demonstrated that miR-186 was upregulated in serum from patients with KD and KD serum could increase miR-186 transcript levels in endothelial cells (HUVECs). Overexpression of miR-186 mimic induced HUVEC apoptosis through mitogen-activated protein kinase (MAPK) activation by targeting and inhibiting SMAD family member 6 (SMAD6). Furthermore, KD serum induced HUVEC apoptosis through miR-186. In conclusion, the present results suggested that KD serum-associated miR-186 has an essential role in endothelial cell apoptosis by activating the MAPK pathway through targeting the SMAD6 gene.

引用

页码：1899 / 1908

页数：10

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