Epigenetic Chemical Probes

被引：27
作者：
Mueller, S. [2 ]
Brown, P. J. [1 ]
机构：
[1] Univ Toronto, Struct Genom Consortium, Toronto, ON, Canada
[2] Univ Oxford, Struct Genom Consortium, Oxford, England
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 92卷 / 06期
基金：
加拿大健康研究院; 英国惠康基金;
关键词：
INHIBITION; BINDING; H3K27; G9A;
D O I：
10.1038/clpt.2012.154
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Epigenetic control of gene expression occurs at two distinct levels: DNA methylation and histone modification. Over the past 10 years, the discovery of epigenetic targets has accelerated to the point where more than 400 domains have been identified that are involved in either DNA methylation, the modification of histones (and some nonhistones), or translation of these modifications into changes in gene expression.
引用
收藏
页码：689 / 693
页数：5
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