Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media

被引：2
作者：
Sachdeva, Harshita [1 ]
Dwivedi, Diksha [1 ]
Saroj, Rekha [1 ]
机构：
[1] Mody Inst Technol & Sci, Fac Engn & Technol, Dept Chem, Sikar 332311, Rajasthan, India
来源：
SCIENTIFIC WORLD JOURNAL | 2013年
关键词：
ONE-POT SYNTHESIS; REUSABLE CATALYST; KAL(SO4)(2)CENTER-DOT-12H(2)O;
D O I：
10.1155/2013/716389
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Alum (KAl(SO4)(2)center dot 12H(2)O) is an inexpensive, efficient, and nontoxic catalyst used for the synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media by the reaction of 3-acetyl pyridine (1), amino acids (2)/(6), and thiosemicarbazide (4) at 80 degrees C. This methodology offers significant improvements for the synthesis of products with regards to the yield of products, simplicity in operation, and green aspects by avoiding toxic catalysts which uphold the motto of green chemistry. Synthesized compounds have been characterized by FT-IR, C-13 NMR, and (HNMR)-H-1 spectroscopy.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] SYNTHESIS, DIMERIC CRYSTAL STRUCTURE, AND FUNGICIDAL ACTIVITY OF 1-(4-METHYLPHENYL)-2-(5-((3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHYL)-4-PHENYL-4H-1,2,4-TRIAZOL-3-YLTHIO)ETHANONE
    Liu, Xing-Hai
    Tan, Cheng-Xia
    Weng, Jian-Quan
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2011, 186 (03) : 558 - 564
  • [2] One Pot Synthesis Of 3-Methyl-1-Phenyl-4-(3′-Methyl-1-Phenyl-4′, 5′-Dihydro-5′-Oxopyrazol-4′-yl- Pyrazolo [5, 4-d]-4H-1-Benzopyran Derivatives
    Akbarzadeh, Abolfath
    Taheri, Milad
    Zare, Mina
    JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2015, 37 (02): : 342 - 347
  • [3] Synthesis, Crystal Structure, DFT Studies and Antifungal Activity of 5-(4-Cyclopropyl-5-((3-fluorobenzyl)sulfonyl)-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole
    Zhai Zhi-Wen
    Shi Yan-Xia
    Yang Ming-Yan
    Sun Zhao-Hui
    Weng Jian-Quan
    Tan Cheng-Xia
    Liu Xing-Hai
    Li Bao-Ju
    Zhang Yong-Gang
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2016, 35 (01) : 25 - 33
  • [4] A New Facet of Azatriene Reactivity: A Short Cut to 5-Amino-3-methyl-4-(1H-pyrrol-1-yl)thiophene-2-carboxylates and 5-Amino-3-methyl-4-(1H-pyrrol-1-yl)thiophene-2-carbonitriles
    Nedolya, Nina A.
    Tarasova, Olga A.
    Albanov, Alexander I.
    Trofimov, Boris A.
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2018, 2018 (17) : 1953 - 1963
  • [5] Synthesis and Antibacterial Activity of Novel Series of 2-(p-Tolyloxy)-3-(5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)quinoline
    Joshi, Ratnadeep S.
    Mandhane, Priyanka G.
    Khan, Wajid
    Gill, Charansingh H.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2011, 48 (04) : 872 - 876
  • [6] 6-Chloro-2-methyl-4-phenyl-3-[1-phenyl-5-(2-thienyl)-4,5-dihydro-1H-pyrazol-3-yl]quinoline
    Fun, Hoong-Kun
    Quah, Ching Kheng
    Sarveswari, S.
    Vijayakumar, V.
    Prasath, R.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O2707 - U395
  • [7] Diversified Synthesis of 2-(4-Oxo[1,2,3]triazolo[1,5-a]quinoxalin-5(4H)-yl)acetamide Derivatives through Ugi-4-CR and Copper-Catalyzed Tandem Reactions
    An, Yu
    He, Huan
    Liu, Tiantian
    Zhang, Yong
    Lu, Xiaoyun
    Cai, Qian
    SYNTHESIS-STUTTGART, 2017, 49 (17): : 3863 - 3873
  • [8] An Efficient Protocol for the One-Pot Synthesis of 4-(2-(4-Bromophenyl)-1,2,3-triazol-4-yl)-3,4-dihydropyrimidin-2(1H)-ones/thiones Catalyzed by Mg(NO3)2
    Liu, Chenjiang
    Zhao, Xinhai
    Li, Yanping
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2011, 48 (01) : 92 - 95
  • [9] Indium chloride catalyzed three-component reaction for the synthesis of 2-((oxoindolin-3-yl)-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamides
    Jiang, Yan-Hong
    Yan, Chao-Guo
    RSC ADVANCES, 2016, 6 (48) : 42173 - 42179
  • [10] An Efficient Synthesis of Novel 7-Aryl-1H-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5-selones from Aroyl Chlorides, Potassium Selenocyanate and 1H-[1,2,4]Triazol-3-ylamine
    Akhavan, Mahboobeh
    Mosslemin, Mohammad H.
    Hassanabadi, Alireza
    Fotooh, Forough Kalantari
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2025, 57 (01) : 90 - 94
12345