SIRT1 metabolic actions: Integrating recent advances from mouse models

被引：102

作者：

Boutant, Marie ^{[1
]}

Canto, Carles ^{[1
]}

机构：

[1] Nestle Inst Hlth Sci SA, EPFL Campus,Batiment G, CH-1015 Lausanne, Switzerland

来源：

MOLECULAR METABOLISM | 2014年 / 3卷 / 01期

关键词：

SIRT1; Transgenic models; Energy homeostasis; Insulin resistance; PANCREATIC BETA-CELLS; STIMULATED INSULIN-SECRETION; SMALL-MOLECULE ACTIVATORS; FATTY-ACID OXIDATION; SKELETAL-MUSCLE; ADIPOSE-TISSUE; HEPATIC GLUCONEOGENESIS; WHITE ADIPOCYTES; NICOTINAMIDE MONONUCLEOTIDE; MITOCHONDRIAL-FUNCTION;

D O I：

10.1016/j.molmet.2013.10.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SIRT1 has attracted a lot of interest since it was discovered as a mammalian homolog of Sir2, a protein that influences longevity in yeast. Intensive early research suggested a key role of SIRT1 in mammalian development, metabolic flexibility and oxidative metabolism. However, it is the growing body of transgenic models that are allowing us to clearly define the true range of SIRT1 actions. In this review we aim to summarize the most recent lessons that transgenic animal models have taught us about the role of SIRT1 in mammalian metabolic homeostasis and lifespan. (C) 2013 The Authors. Published by Elsevier GmbH.Open access under CC BY license.

引用

页码：5 / 18

页数：14

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