Synthesis of base-modified noraristeromycin derivatives and their inhibitory activity against human and Plasmodium falciparum recombinant S-adenosyl-L-homocysteine hydrolase

被引：30
|
作者：
Kitade, Y [1 ]
Kozaki, A [1 ]
Miwa, T [1 ]
Nakanishi, M [1 ]
机构：
[1] Gifu Univ, Fac Engn, Dept Biomol Sci, Lab Mol Biochem, Gifu 5011193, Japan
来源：
TETRAHEDRON | 2002年 / 58卷 / 07期
关键词：
enzyme inhibitors; antivirals; nucleosides; hydrolysis; antiparasitics;
D O I：
10.1016/S0040-4020(01)01247-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Noraristeromycin derivatives possessing 2- or 8-position modified adenine or 8-aza-7-deazaadenine were synthesized, and their inhibitory activity against human and Plasmodium falciparum (P. falciparum) recombinant SAH hydrolases was investigated. Among these noraristeromycin derivatives, 2-aminonoraristeromycin selectively showed inhibitory activity against P. falciparum recombinant SAH hydrolase. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1271 / 1277
页数：7
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