Towards the clinical application of X-ray phase contrast imaging

被引:21
作者
Williams, I. M. [1 ]
Siu, K. K. W. [1 ,4 ]
Runxuan, G. [2 ]
He, X. [2 ]
Hart, S. A. [3 ]
Styles, C. B. [5 ]
Lewis, R. A. [1 ,4 ]
机构
[1] Monash Univ, Sch Phys, Clayton, Vic 3800, Australia
[2] Dept Med Imaging & Radiat Sci, Clayton, Vic 3800, Australia
[3] Monash Breast Surg Unit, Clayton, Vic 3168, Australia
[4] Monash Univ, Monash Ctr Synchrotron Sci, Clayton, Vic 3800, Australia
[5] Peter MacCallum Canc Inst, Clayton, Vic 8006, Australia
关键词
Mammography; Phase contrast imaging; Propagation-based imaging; X-ray;
D O I
10.1016/j.ejrad.2008.04.042
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Synchrotron-based propagation-based imaging, a type of phase contrast imaging, produces better soft tissue image contrast than conventional radiography. To determine whether the technique is directly transferable to the clinical environment for routine diagnostic or screening imaging, a micro-focus (100 mu m spot-size) Molybdenum X-ray source with 0.03 mm molybdenum filtration was installed at a local hospital. Breast tissue samples, excised masses and mastectomies, were obtained directly from surgery and imaged at three geometries. The first geometry was optimised for visualizing phase contrast effects using a ray-line argument, the second was the same as that employed by Konica-Minolta in their commercial phase contrast system, and the third was the conventional contact arrangement. The three images taken of each tissue sample were comparatively scored in a pair-wise fashion. Scoring was performed by radiologist expert in mammography, general radiologists, associated clinicians and radiographers on high-resolution mammography rated monitors at two separate locations. Scoring indicated that the optimised and Konica geometries both outperformed the conventional mammographic geometry. An unexpected complication within the trial was the effect that the scoring platform and the associated display tools had on some of the scorer's responses. Additionally, the trial revealed that none of the conventional descriptors for image quality were adequate in the presence of phase contrast enhancements. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:S73 / S77
页数:5
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