Palladium-catalyzed [4+3] annulation of 2-bromobiphenyls and epoxides for the assembly of dihydrodibenzo[b,d]oxepines

被引：3
作者：
Shen, Zipei [1 ]
Zhou, Lan [1 ]
Wu, Chenggui [2 ]
Zhou, Qianghui [1 ,3 ]
Cheng, Hong-Gang [1 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, Sauvage Ctr Mol Sci, Engn Res Ctr Organosilicon Cpds & Mat,Minist Educ, Wuhan 430072, Peoples R China
[2] Anhui Univ Chinese Med, Minist Educ, Key Lab Xinan Med, Hefei, Anhui, Peoples R China
[3] Wuhan Univ, Inst Adv Studies, Wuhan 430072, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 45期
基金：
中国国家自然科学基金;
关键词：
C-H ACTIVATION; O-BROMOBENZYL ALCOHOLS; DIRECT ARYLATION; ARYL IODIDES; ALKYLATION; 2-IODOBIPHENYLS; FLUOREN-9-ONES; TRIPHENYLENES; CYCLOCARBONYLATION; 2-LODOBIPHENYLS;
D O I：
10.1039/d2ob01720b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the construction of dihydrodibenzo[b,d]oxepines is reported. This approach involves direct C-H and C-O bond activation followed by a ring annulation and features readily available starting materials, a broad substrate scope, good step economy and good scalability.
引用
收藏
页码：8869 / 8872
页数：4
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