Formation of ordered domains in membrane-bound DNA

被引：57
作者：
Dan, N
机构：
[1] Department of Chemical Engineering, University of Delaware, Newark
来源：
BIOPHYSICAL JOURNAL | 1996年 / 71卷 / 03期
关键词：
D O I：
10.1016/S0006-3495(96)79326-8
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The interactions between DNA molecules adsorbed on fluid membranes are calculated. The adsorbing DNA perturbs the equilibrium packing of the lipids, thereby giving rise to membrane-induced, attractive interactions. These balance the direct repulsive interactions between DNA molecules. As a result, DNA adsorbed on membranes is predicted to form ordered domains characterized by a finite spacing, which varies with the membrane characteristics and the solution Debye screening length. Comparing the model predictions to recent experiments (Yang et al. 1996) yields excellent agreement with only one free (i.e., experimentally unknown) parameter.
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页码：1267 / 1272
页数：6
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