Bilirubin in the Liver-Gut Signaling Axis

被引：173

作者：

Hamoud, Abdul-Rizaq ^{[1
]}

Weaver, Lauren ^{[1
]}

Stec, David E. ^{[2
]}

Hinds, Terry D., Jr. ^{[1
]}

机构：

[1] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Ctr Hypertens & Personalized Med, Toledo, OH 43614 USA

[2] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Mississippi Ctr Obes Res, Jackson, MS 39216 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 03期

关键词：

INCREASES INSULIN SENSITIVITY; BILE-ACID TRANSPORTERS; PREGNANE-X-RECEPTOR; FATTY LIVER; SERUM BILIRUBIN; HEPATIC STEATOSIS; GILBERTS-SYNDROME; ENTEROHEPATIC CIRCULATION; UGT1A1-ASTERISK-28; ALLELE; BILIVERDIN REDUCTASE;

D O I：

10.1016/j.tem.2018.01.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bilirubin is a component of the heme catabolic pathway that is essential for liver function and has been shown to reduce hepatic fat accumulation. High plasma bilirubin levels are reflective of liver disease due to an injurious effect on hepatocytes. In healthy liver, bilirubin is conjugated and excreted to the intestine and converted by microbes to urobilinoids, which are reduced to the predominant pigment in feces, stercobilin, or reabsorbed. The function of urobilinoids in the gut or their physiological relevance of reabsorption is not well understood. In this review, we discuss the relationship of hepatic bilirubin signaling to the intestinal microbiota and its regulation of the liver-gut axis, as well as its capacity to mediate these processes.

引用

页码：140 / 150

页数：11

共 84 条

[31]

Konícková R, 2012, ACTA BIOCHIM POL, V59, P289

[32]

Kosters A, 2008, XENOBIOTICA, V38, P1043, DOI [10.1080/00498250802040584, 10.1080/00498250802040584 ]

[33] Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: A favorable endogenous response [J].