Construction of Gene Network in Type 2 Diabetes with Genome-Wide Association Study

A genome-wide association analysis (GWAS) based on the research results, the local gene networks a preliminary establishment of susceptibility genes of type 2 diabetes mellitus, for future gene-gene interactions, provides reference for the research on gene environment interaction. 65 candidate genes selected from the study by GWAS of susceptibility genes of type 2 Diabetes Association, it selects 2 or more pathways target genes from 27, and through the selection of screening, intermediate gene pathway, construct local gene network, and use Ai CS6 software to draw network diagram. It consists of the following steps: (1) building a network of basic information of genes and pathways obtained by the KEGG and Genecards database; (2) establish a primary gene network; (3) selecting the middle gene; (4) the gene level two connection; (5) construction and mapping network local gene network. A total of 1 genes including the gene and a number of intermediate genes, as well as a series of linked genes and intermediate molecules, were obtained. The network contains 2 0 biological pathways. Local gene network conclusion this study obtained a more intuitive and comprehensive display of beta cell dysfunction and insulin resistance in susceptible relationship between genes, which can provide reference for study of molecular pathogenesis of type 2 diabetes in depth.