Graphene-Induced Adsorptive and Optical Artifacts During In Vitro Toxicology Assays

被引：41
作者：
Creighton, Megan A. [1 ]
Rene Rangel-Mendez, J. [3 ]
Huang, Jiaxing [4 ]
Kane, Agnes B. [2 ]
Hurt, Robert H. [1 ]
机构：
[1] Brown Univ, Sch Engn, Providence, RI 02912 USA
[2] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA
[3] Inst Potosino Invest Cient & Tecnol, Div Ciencias Ambientales, San Luis Potosi 78216, Mexico
[4] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA
来源：
SMALL | 2013年 / 9卷 / 11期
基金：
美国国家科学基金会;
关键词：
WALLED CARBON NANOTUBES; AQUEOUS-SOLUTION; PROTEIN CORONA; OXIDE; NANOMATERIALS; FLUORESCENCE; OXIDATION; BIOCOMPATIBILITY; CYTOTOXICITY; MOLECULES;
D O I：
10.1002/smll.201202625
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Graphene materials can deplete essential micronutrients from cell culture media and potentially interfere with probe dyes used during in vitro analysis of cell viability and function by (1) adsorbing dyes before they can interact with their target biomolecule, (2) quenching fluorescence after the interaction, and/or (3) absorbing or scattering light, which are issues for both colorimetric and fluorescent assays. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1921 / 1927
页数：7
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