Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney

被引：179

作者：

Kumar, Sanjeev ^{[1
]}

Liu, Jing ^{[1
]}

Pang, Paul ^{[1
]}

Krautzberger, A. Michaela ^{[1
]}

Reginensi, Antoine ^{[2
]}

Akiyama, Haruhiko ^{[3
]}

Schedl, Andreas ^{[2
]}

Humphreys, Benjamin D. ^{[4
,5
]}

McMahon, Andrew P. ^{[1
]}

机构：

[1] Univ So Calif, Dept Stem Cell Biol & Regenerat Med, Eli & Edythe Broad, CIRM Ctr Regenerat Med & Stem Cell Res,WM Keck Sc, Los Angeles, CA 90089 USA

[2] Univ Nice Sophia Anitpolis, INSERM U636, Ctr Biochim, F-06108 Nice 02, France

[3] Gifu Univ, Dept Orthoped, Gifu 5011194, Japan

[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Renal Div, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

CELL REPORTS | 2015年 / 12卷 / 08期

关键词：

SRY-RELATED GENE; EPITHELIAL-CELLS REPAIR; AUTOSOMAL SEX REVERSAL; STEM-CELLS; CAMPOMELIC DYSPLASIA; IN-VIVO; REGENERATION; EXPRESSION; FAILURE; MOUSE;

D O I：

10.1016/j.celrep.2015.07.034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

After acute kidney injury (AKI), surviving cells within the nephron proliferate and repair. We identify Sox9 as an acute epithelial stress response in renal regeneration. Translational profiling after AKI revealed a rapid upregulation of Sox9 within proximal tubule (PT) cells, the nephron cell type most vulnerable to AKI. Descendants of Sox9(+) cells generate the bulk of the nephron during development and regenerate functional PT epithelium after AKI-induced reactivation of Sox9 after renal injury. After restoration of renal function post-AKI, persistent Sox9 expression highlights regions of unresolved damage within injured nephrons. Inactivation of Sox9 in PT cells pre-injury indicates that Sox9 is required for the normal course of post-AKI recovery. These findings link Sox9 to cell intrinsic mechanisms regulating development and repair of the mammalian nephron.

引用

页码：1325 / 1338

页数：14

共 55 条

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