Venous sinus thrombosis leading to stroke in a patient with sickle cell disease on hydroxyurea and high hemoglobin levels: Treatment with thrombolysis

被引：28

作者：

Sidani, Charf A. ^{[2
]}

Ballourah, Walid ^{[1
]}

El Dassouki, Mohamad ^{[3
]}

Muwakkit, Samar ^{[1
]}

Dabbous, Ibrahim ^{[1
]}

Dahoui, Hanan ^{[1
]}

Al-Kutoubi, Aghiad ^{[2
]}

Abboud, Miguel R. ^{[1
]}

机构：

[1] Amer Univ Beirut, Med Ctr, Childrens Canc Ctr Lebanon, Div Pediat, Beirut, Lebanon

[2] Amer Univ Beirut, Med Ctr, Dept Radiol, Beirut, Lebanon

[3] Rafic Hariri Univ Hosp, Dept Neurol, Beirut, Lebanon

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2008年 / 83卷 / 10期

关键词：

D O I：

10.1002/ajh.21261

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 21-year-old man with homozygous sickle cell disease maintained on hydroxyurea for 1 year developed thrombosis of the superior sagittal, right transverse, and right sigmoid dural sinuses with a large venous infarct. He was successfully treated with endovascular thrombolysis. Investigation did not reveal any inherited or acquired hypercoagulable state. This patient however had consistently elevated hemoglobin levels both at the time of the initial event and on follow up. One year later he developed symptomatic avascular necrosis of the right hip. High hemoglobin levels resulting from hydroxyurea therapy may have contributed to development of complications in this patient.

引用

页码：818 / 820

页数：3

共 21 条

[1] Sickle cell trait and the risk of venous thromboembolism among blacks [J].

Austin, Harland ;

Key, Nigel S. ;

Benson, Jane M. ;

Lally, Cathy ;

Dowling, Nicole F. ;

Whitsett, Carolyn ;

Hooper, W. Craig .

BLOOD, 2007, 110 (03) :908-912

[2] EFFECT OF HYDROXYUREA ON THE RHEOLOGICAL PROPERTIES OF SICKLE ERYTHROCYTES INVIVO [J].

BALLAS, SK ;

DOVER, GJ ;

CHARACHE, S .

AMERICAN JOURNAL OF HEMATOLOGY, 1989, 32 (02) :104-111

[3]

CHARACHE S, 1982, BLOOD CELLS, V8, P103

[4]

CICCONE A, 2004, COCHRANE DB SYST REV, V1

[5] Dural venous sinus thrombosis in a patient with sickle cell disease: Case report and literature review [J].

Ciurea, SO ;

Thulborn, KR ;

Gowhari, M .

AMERICAN JOURNAL OF HEMATOLOGY, 2006, 81 (04) :290-293

[6] Sickle cell disease and internal cerebral vein thrombosis. [J].

Di Roio, C ;

Jourdan, C ;

Terrier, A ;

Artru, F .

ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION, 1997, 16 (08) :967-969

[7] SUPERIOR SAGITTAL SINUS THROMBOSIS WITH INFARCTION IN SICKLE-CELL TRAIT [J].

FELDENZER, JA ;

BUECHE, MJ ;

VENES, JL ;

GEBARSKI, SS .

STROKE, 1987, 18 (03) :656-660

[8] Therapy with hydroxyurea is associated with reduced adhesion molecule gene and protein expression in sickle red cells with a concomitant reduction in adhesive properties [J].

Gambero, Sheley ;

Canalli, Andreia A. ;

Traina, Fabiola ;

Albuquerque, Dulcineia M. ;

Saad, Sara T. O. ;

Costa, Fernando F. ;

Conran, Nicola .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2007, 78 (02) :144-151

[9] Arterial blood pressure and hyperviscosity in sickle cell disease [J].

Johnson, CS .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2005, 19 (05) :827-+

[10] Risk factors for recurrent venous thromboembolism in the European collaborative paediatric database on cerebral venous thrombosis:: a multicentre cohort study [J].

Kenet, Gili ;

Kirkham, Fenella ;

Niederstadt, Thomas ;

Heinecke, Achim ;

Saunders, Dawn ;

Stoll, Monika ;

Brenner, Benjamin ;

Bidlingmaier, Christoph ;

Heller, Christine ;

Knoefler, Ralf ;

Schobess, Rosemarie ;

Zieger, Barbara ;

Sebire, Guillaume ;

Nowak-Goettl, Ulrike .

LANCET NEUROLOGY, 2007, 6 (07) :595-603

← 1 2 3 →