Chromium-Catalyzed Activation of Acyl C-O Bonds with Magnesium for Amidation of Esters with Nitroarenes

被引：51
作者：
Ling, Liang [1 ]
Chen, Changpeng [1 ,2 ]
Luo, Meiming [1 ]
Zeng, Xiaoming [1 ,2 ]
机构：
[1] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan, Peoples R China
[2] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710054, Shaanxi, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 06期
基金：
中国国家自然科学基金;
关键词：
SECONDARY AMIDES; GRIGNARD-REAGENTS; TRANSAMIDATION; CLEAVAGE; ETHERS; ARYLMAGNESIATION; REDUCTION; COMPLEX; ACIDS;
D O I：
10.1021/acs.orglett.9b00554
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Here, we report a chromium-catalyzed activation of acyl C-O bonds with magnesium for amidation of esters with nitroarenes. Low-cost chromium(III) chloride shows high reactivity in promoting amidation by using magnesium as reductant and chlorotrimethylsilane as additive. It provides a step-economic strategy to the synthesis of centrally important amide motifs using inexpensive and air-stable nitroarenes as amino sources.
引用
收藏
页码：1912 / 1916
页数：5
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