Chromium-Catalyzed Activation of Acyl C-O Bonds with Magnesium for Amidation of Esters with Nitroarenes

被引：54

作者：

Ling, Liang ^{[1
]}

Chen, Changpeng ^{[1
,2
]}

Luo, Meiming ^{[1
]}

Zeng, Xiaoming ^{[1
,2
]}

机构：

[1] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan, Peoples R China

[2] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710054, Shaanxi, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 06期

基金：

中国国家自然科学基金;

关键词：

SECONDARY AMIDES; GRIGNARD-REAGENTS; TRANSAMIDATION; CLEAVAGE; ETHERS; ARYLMAGNESIATION; REDUCTION; COMPLEX; ACIDS;

D O I：

10.1021/acs.orglett.9b00554

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, we report a chromium-catalyzed activation of acyl C-O bonds with magnesium for amidation of esters with nitroarenes. Low-cost chromium(III) chloride shows high reactivity in promoting amidation by using magnesium as reductant and chlorotrimethylsilane as additive. It provides a step-economic strategy to the synthesis of centrally important amide motifs using inexpensive and air-stable nitroarenes as amino sources.

引用

收藏

页码：1912 / 1916

页数：5

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