Comparative Study of Antimicrobial Agents against Pathogens Associated with Diarrheal Disorders

被引：0

作者：

Khan, Ibrahim ^{[1
]}

Musaddiq, M. ^{[1
]}

机构：

[1] Shri Shivaji Coll Arts Commerce & Sci, Dept Microbiol, Akola, India

来源：

JOURNAL OF PURE AND APPLIED MICROBIOLOGY | 2012年 / 6卷 / 03期

关键词：

Diarrhea; Ampicillin; Ceftriaxone; Norfloxacin; Nalidixic acid; Minimum Inhibitory Concentration (MIC); TRAVELERS DIARRHEA; BACTERIAL ENTEROPATHOGENS; ANTIBIOTIC-RESISTANCE; PREVENTION; THAILAND; TRENDS;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Comparative study of antimicrobial activity of eight antibiotics which are used conventionally for the treatment of diarrhea, i.e. Ampicillin, Ceftriaxone, Doxycycline, Levofloxacin, Norfloxacin, Nalidixic acid, Trimethoprim sulfamethoxazoleand Tetracycline was studied with the use of pathogensisolated and identified from the stool samples collected from various diarrheal patients admitted at various Government and Private hospitals of Akola district. The antimicrobial activity was determined by studying Minimum Inhibitory Concentration (MIC)using Clinical and Laboratory Standard Institute (CLSI) guidelines. The microdilution procedure using 96 wells microdilutionplates was employed. Results revealed Increase in microbial resistance by enteric pathogen against antimicrobials Ampicillin, Nalidixic acid, Tetracycline and Doxycycline with high MIC50 and MIC90 values, However Levofloxacin, Ceftriaxone and Norfloxacin revealed promising MIC activity.E.coli shows high resistance as compared to Salmonella and Shigella species.

引用

页码：1391 / 1395

页数：5

共 12 条

[1] COMPARATIVE INVITRO ACTIVITIES OF 10 ANTI-MICROBIAL AGENTS AGAINST BACTERIAL ENTEROPATHOGENS [J].

CARLSON, JR ;

THORNTON, SA ;

DUPONT, HL ;

WEST, AH ;

MATHEWSON, JJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 24 (04) :509-513

[2]

DUPONT HL, 1993, NEW ENGL J MED, V328, P1821, DOI 10.1056/NEJM199306243282507

[3] TRAVELERS DIARRHEA - APPROACHES TO PREVENTION AND TREATMENT [J].

ERICSSON, CD ;

DUPONT, HL .

CLINICAL INFECTIOUS DISEASES, 1993, 16 (05) :616-624

[4] In vitro antimicrobial susceptibility testing of bacterial enteropathogens causing traveler's diarrhea in four geographic regions [J].

Gomi, H ;

Jiang, ZD ;

Adachi, JA ;

Ashley, D ;

Lowe, B ;

Verenkar, MP ;

Steffen, R ;

Dupont, HL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (01) :212-216

[5] Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years [J].

Hoge, CW ;

Gambel, JM ;

Srijan, A ;

Pitarangsi, C ;

Echeverria, P .

CLINICAL INFECTIOUS DISEASES, 1998, 26 (02) :341-345

[6] USE OF AZITHROMYCIN FOR THE TREATMENT OF CAMPYLOBACTER ENTERITIS IN TRAVELERS TO THAILAND, AN AREA WHERE CIPROFLOXACIN RESISTANCE IS PREVALENT [J].

KUSCHNER, RA ;

TROFA, AF ;

THOMAS, RJ ;

HOGE, CW ;

PITARANGSI, C ;

AMATO, S ;

OLAFSON, RP ;

ECHEVERRIA, P ;

SADOFF, JC ;

TAYLOR, DN .

CLINICAL INFECTIOUS DISEASES, 1995, 21 (03) :536-541

[7] EPIDEMIC SHIGA-BACILLUS DYSENTERY IN CENTRAL-AMERICA .1. ETIOLOGIC INVESTIGATIONS IN GUTEMALA, 1969 [J].

MATA, LJ ;

GANGAROSA, EJ ;

CACERES, A ;

PERERA, DR ;

MEJICANOS, ML .

JOURNAL OF INFECTIOUS DISEASES, 1970, 122 (03) :170-+

[8]

Murray B E, 1986, REV INFECT DIS S2, V8, pS172

[9] Antibiotic resistance trends in enteropathogenic bacteria isolated in 1985-1987 and 1995-1998 in Barcelona [J].

Prats, G ;

Mirelis, B ;

Llovet, T ;

Muñoz, C ;

Miró, E ;

Navarro, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (05) :1140-1145

[10]

Rossignol Jean-Francois, 2007, US GASTROENTEROL REV, P76

← 1 2 →