Predictable phase-separated proteins

被引：17
|
作者：
Ray, Soumik [1 ]
Maji, Samir K. [1 ]
机构：
[1] Indian Inst Technol, Dept Biosci & Bioengn, Mumbai, Maharashtra, India
来源：
NATURE CHEMISTRY | 2020年 / 12卷 / 09期
关键词：
D O I：
10.1038/s41557-020-0532-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An approach to design artificial intrinsically disordered proteins using a short peptide as a repeating unit has been reported. This design enables the phase behaviour of the protein to be finely tuned inside cells and enabled the formation of phase-separated condensates that can modulate chemical reactions.
引用
收藏
页码：787 / 789
页数：3
相关论文
共 50 条
  • [21] Anisotropically phase-separated biphasic particles
    Teranishi, T
    SMALL, 2006, 2 (05) : 596 - 598
  • [22] EVOLUTIONARY SIGNIFICANCE OF PHASE-SEPARATED MICROSYSTEMS
    FOX, SW
    ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES, 1976, 7 (01): : 50 - 68
  • [23] Tunneling magnetoresistance of phase-separated manganites
    Sboychakov, AO
    Rakhmanov, AL
    Kugel, KI
    Kagan, MY
    Brodsky, IV
    JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2003, 258 : 296 - 299
  • [24] Characterizing the metabolomes of phase-separated condensates
    Dumelie, Jason G.
    Jaffrey, Samie R.
    NATURE CHEMICAL BIOLOGY, 2024, 20 (03) : 273 - 274
  • [25] Phase-Separated Interpenetrating Polymer Networks
    Lipatov, Yuri S.
    Alekseeva, Tatiana T.
    PHASE-SEPARATED INTERPENETRATING POLYMER NETWORKS, 2007, 208 : 1 - 227
  • [26] STRESS IN LEACHED PHASE-SEPARATED GLASS
    SCHERER, GW
    DREXHAGE, MG
    JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 1985, 68 (08) : 419 - 426
  • [27] Phase-separated droplets swim to their dissolution
    Jambon-Puillet, Etienne
    Testa, Andrea
    Lorenz, Charlotta
    Style, Robert W.
    Rebane, Aleksander A.
    Dufresne, Eric R.
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [28] Tunneling magnetoresistance of phase-separated manganites
    Sboychakov, AO
    Rakhmanov, AL
    Kugel', KI
    Kagan, MY
    Brodsky, IV
    JOURNAL OF EXPERIMENTAL AND THEORETICAL PHYSICS, 2002, 95 (04) : 753 - 761
  • [29] Induced Mixing of Phase-Separated Lipid Bilayers by Steric Pressure between Adsorbed Proteins
    Zeno, Wade
    Johnson, Kaitlin E.
    Sasaki, Darryl Y.
    Longo, Marjorie L.
    BIOPHYSICAL JOURNAL, 2017, 112 (03) : 42A - 42A
  • [30] Particulate growth in phase-separated polymer blends
    Cavanaugh, TJ
    Nauman, EB
    JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 1998, 36 (12) : 2191 - 2196
12345